First demonstration of a lack of viral sequence evolution in a nonprogressor
, defining replication-incompetent HIV-1 infection.
4-5) The classic example is the Sydney Blood Bank Cohort, where a group of 8 recipients of blood products were infected with a nef/LTR-deleted strain of HIV from a long-term nonprogressor
(reviewed in Zaunders et al (6)).
Braibant M, Xie J, Samri A, Agut H, Autran B, Barin E Disease progression due to dual infection in an HLA-B57- positive asymptomatic long-term nonprogressor
infected with a nef-defective HIV-1 strain.
Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor
status in human immunodeficiency virus-1 infected individuals.
An HIV+ person who shows no signs or symptoms of disease progression for over 12 years is called a nonprogressor
or a long-term nonprogressor
Increased pDCs have been associated with nonprogressor
Finally, could you turn somebody who is a patient with early disease into somebody who is more like a long-term nonprogressor
by boosting HIV-specific immunity?
Only one nonprogressor
in a cohort of American hemophilic LTNPs has been identified as carrying nef-deleted virus (J Infect Dis, 180, p.
sup],, This is also the reason why long-term nonprogressors
have very low levels of HIV DNA, outside of that from defective virus at the beginning of infection.
116-124] Nef epitope elicited CD8 T cell interferon-responses in long-term nonprogressors
, whereas progressors did not maintain an specific CD8 T cell response to this epitope, suggesting an exhausted phenotype of CD8 T cells in progressors, who also show an enhanced level of expression of inhibitory receptor "programmeddeath1"(PD-1).
fermentans in patients seropositive for HIV regardless of whether they were nonprogressors
, slow progressors, or rapid progressors .
preferentially maintain highly functional HIV-specific [CD8.