Increased pDCs have been associated with nonprogressor
Finally, could you turn somebody who is a patient with early disease into somebody who is more like a long-term nonprogressor
by boosting HIV-specific immunity?
Only one nonprogressor
in a cohort of American hemophilic LTNPs has been identified as carrying nef-deleted virus (J Infect Dis, 180, p.
4-5) The classic example is the Sydney Blood Bank Cohort, where a group of 8 recipients of blood products were infected with a nef/LTR-deleted strain of HIV from a long-term nonprogressor
(reviewed in Zaunders et al (6)).
Braibant M, Xie J, Samri A, Agut H, Autran B, Barin E Disease progression due to dual infection in an HLA-B57- positive asymptomatic long-term nonprogressor
infected with a nef-defective HIV-1 strain.
An HIV+ person who shows no signs or symptoms of disease progression for over 12 years is called a nonprogressor
or a long-term nonprogressor
Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor
status in human immunodeficiency virus-1-infected individuals.
Furthermore, women with progressive disease were nearly five times more likely to give birth before 35 weeks' gestation, compared with those women who are nonprogressors
One series of terms, for example, describes unique individual responses to HIV infection: rapid progressors, nonprogressors
, and long-term survivors.
Medical researchers are very interested in these long-term nonprogressors
as they are called, because they may shed some light on the characteristics of the immune system that could be boosted, for example, by a vaccine, to protect the average person against HIV infection.
These "Immune Non Responders," patients with progressive or unstable disease, are in marked contrast to nonprogressors
or "elite controllers" who, like their simian counterparts noted above, show no evidence of HIV progression and have stable CD4+ T-cell counts even after years of HIV infection.
In these long-term nonprogressors
, HIV-1 antibody is easily demonstrated, but these individuals show low or undetectable HIV-1 RNA loads in the assays available to clinical laboratories.