nonpolar amino acid

non·po·lar a·mi·no ac·id

an α-amino acid in which the functional group attached to the α-carbon (that is, R in RCH(NH3+)COO-) has hydrophobic properties, for example, valine, leucine.
References in periodicals archive ?
The Arg114Pro amino acid substitution would produce a change from a hydrophilic positively charged, polar amino acid on the amino-terminal domain (residues 1-164) to a hydrophobic nonpolar amino acid.
The replacement of P92S and A277T were conversion of non-polar to polar amino acids whereas the change of T156A T191A and T239M were from polar to nonpolar amino acids.
In sickle cell anemia, these glutamic acids are replaced by valines, large nonpolar amino acids.