nonoxynol-9


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Related to nonoxynol-9: spermicide

nonoxynol-9

(nŏn-ŏk′sə-nôl′nīn′, -nŏl′-, -nōl′-)
n.
A spermicide widely used in contraceptive creams, foams, and lubricants.

nonoxynol-9

A SURFACTANT spermicidal drug intended for use in conjunction with barrier contraceptives. It is available as a foam, pessary, gel, or cream. Brand names are Delfen, Double Check, Ortho-Forms, Duragel, Gynol II and Ortho-Creme.
References in periodicals archive ?
Rosenberg stated that this unique combination could have important implications for global world health, in part because, according to the World Health Organization and FDA-mandated labeling requirements in effect since December 2007, the currently marketed nonoxynol-9 vaginal gel may actually increase the risk of acquisition of HIV in some circumstances.
A similar effect was seen in Nonoxynol-9 treated Sertoli cells which served as the positive controls.
Hence the objective of this study was to isolate the protein from these extracts and to study its effects on sperm in vitro in comparison with nonoxynol-9, a known spermicide.
Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial.
In December 2007, the Food and Drug Administration (FDA) issued a rule requiring over-the-counter vaginal contraceptives (gels, foams, creams) that contain nonoxynol-9 (N-9) to carry warning labels alerting the consumer that N-9 does not reduce the risk of HIV infection and could increase a woman's risk of becoming infected.
For example, three programs promoted the use of the spermicide nonoxynol-9, but the report states that recent research has shown that nonoxynol-9 is ineffective against STDs and has the potential to increase the risk of transmission.
Nonoxynol-9, the most widely used spermicide, has come under scrutiny because its strong detergent properties--which make it lethal to sperm--irritate the lining of the genital tract of some women.
While the final data on what went wrong with the Ushercell trial remained outstanding at the time of writing, researchers believe nonoxynol-9 harmed participants by causing lesions in the vagina.
Specifically, the report takes issue with the use in one curriculum of the term "dental dam" instead of "rubber dam," notes that three programs included out-dated information on the spermicide nonoxynol-9 and faults one program for citing an inaccurate condom failure rate (12% rather than 15%).
17) Frequent use of spermicides containing nonoxynol-9 (N-9) may increase the risk of re-infection with other strains of HIV because N-9 can disrupt the lining of the vagina, making it more vulnerable to infection.
Spermicides--as well as diaphragms and cervical caps, which are used in conjunction with spermicides--are not recommended for women living with HIV, on the basis of findings that question the safety of nonoxynol-9.