Older age, the use of peripheral stem cells, a higher degree of histocompatibility, unrelated donors, and nonmyeloablative
conditioning regimens are major risk factors for an increased risk of aGvHD.
Upon enrollment, patients receive a lymphodepletion regimen consisting of fludarabine and cyclophasphamide followed by 1x1062x106 CAR T cells/kg, nonmyeloablative
conditioning and Haplo-HSCT
Comparison of minimal residual disease as outcome predictor for AML patients in first complete remission undergoing myeloablative or nonmyeloablative
allogeneic hematopoietic cell transplantation.
HLA-haploidentical bone marrow transplan-tation for hematologic malignancies using nonmyeloablative
conditioning and high-dose, posttransplantation cyclopho-sphamide.
Graft rejection after hematopoietic cell transplantation with nonmyeloablative
(24) found a significantly lower cumulative incidence of IPS in patients at 120 days after nonmyeloablative
conditioning (2.2% vs.
Although the elimination of particular DAMPs diminishes aGVHD manifestation in preclinical models, such approach is controversial in clinical praxis especially in HSCT after reduced and nonmyeloablative
conditionings with minimal conditioning-induced tissue damage .
The first infusion was given 6-8 weeks following allogeneic HSCT with nonmyeloablative
conditioning (fludarabine-based with alemtuzumab) in 30 adult patients with hematologic malignancies (14 undergoing MRD HSCT and 16 undergoing mismatched-related donor (MMRD) HSCT).
Symons et al., "HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative
conditioning and high-dose, posttransplantation cyclophosphamide," Biology of Blood and Marrow Transplantation, vol.
Stracieri et al., "Autologous nonmyeloablative
hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus," JAMA, vol.
He underwent nonmyeloablative
allogeneic hematopoietic stem cell transplant (HSCT) in 2013 and had numerous complications.
Yajima et al., "Humanized NOD/SCID/IL2Rynull mice transplanted with hematopoietic stem cells under nonmyeloablative
conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis," Journal of Virology, vol.