Multiphase imaging of the abdomen was performed by intravenous application of 80-150 mL of nonionic contrast agent
(Iomeron, iodine concentration 400 mg/mL; Ultravist, iodine concentration 370 mg/mL; or Visipaque, iodine concentration 320 mg/mL) in bolus through venous cannulas, size 18-20 gauge.
Adverse delayed cutaneous events have been noted significantly (P < 0.05) more often with a dimeric nonionic agent (16.4%) than with a monomeric nonionic contrast agent
All patients with a preoperative serum creatinine level of at least 1.5 mg/dL underwent several measures to reduce their risk of contrast-induced nephropathy: They were hydrated perioperatively, they received mannitol intraoperatively, and they did not receive any potentially nephrotoxic drugs during their procedure aside from a nonionic contrast agent
Approximately 10% of all imaging studies performed in the United States each year, or about 10 million exams, involve contrast media. Currently, nonionic contrast costs 10 to 15 times more than ionic contrast. For example, 50 mL of iopamidol (Isovue 300), a frequently used nonionic contrast agent
, costs approximately $80, compared with $5 for diatrizoate (Renografin 60), an ionic agent.
In 1974, this procedure was transformed with metrizamide and years later with iohexol, both nonionic contrast agents .
The adverse reactions associated with intrathecal injections of nonionic contrast agents are headache, nausea, vomiting, or dizziness, which may largely be attributed to pressure loss in the subarachnoid space resulting from intracranial hypotension from leakage at the puncture site.
Cross, "A prospective trial of ionic vs nonionic contrast agents
in routine clinical practice: comparison of adverse effects," American Journal of Roentgenology, vol.
Dialysis is not indicated immediately after administration of nonionic contrast agents
in patients with end-stage renal disease treated by maintenance dialysis.
Universal implementation of lower osmotic, nonionic contrast agents
has significantly reduced serious acute systemic side effects  making these drugs among the safest in medical use today.
Fewer than 10 years ago, the authors decided which patients should receive ionic versus nonionic contrast agents
based on the patient's age, medical histories, known allergies, and the examination being performed.
Pulmonary embolism: Prospective comparison of isoosmolar and low-osmolarity nonionic contrast agents
for contrast enhancement at CT angiography.