noninferiority trial


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Related to noninferiority trial: equivalence trial, superiority trial

noninferiority trial

A study to determine if a treatment is no worse than the currently accepted therapy.
See also: trial
References in periodicals archive ?
In this randomized, noninferiority trial, 217 participants with type 1 diabetes who used an insulin pump were randomized either to CGM only (142 individuals) or to CGM with additional BGM before an insulin bolus was administered (75 individuals).
The current noninferiority trial used few inclusion criteria--just age 18-40 years and first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycle--to prospectively enroll 1,099 women and evenly randomize them to a classic short GnRH-antagonist protocol or a classic long GnRH-agonist protocol.
The researchers directly compared cytisine with nicotine replacement therapy in an open-label, randomized, noninferiority trial in New Zealand.
A randomized, double-blind, noninferiority trial in postmenopausal women.
This multicenter, randomized, noninferiority trial from the Urinary Incontinence Treatment Network found no significant differences in 1-year outcomes between women who underwent urodynamic testing versus those who did not.
The study was a noninferiority trial, which meant that the researchers aimed to show that a new treatment (here, clinically driven monitoring) was not worse than a standard treatment (routine monitoring) by a prespecified, clinically meaningful degree; they determined that the upper 95% confidence limit of the hazard ratio for the measure encompassing death and new stage 4 conditions could not exceed 1.
39) However, this last study was designed as a noninferiority trial and its results do not negate the prior study's findings.
For the current noninferiority trial, known as PROBAAT-II, the researchers set out to study the safety and effectiveness of labor induction using oral misoprostol, compared with transcervical catheter in term pregnant women with an unfavorable cervix.
Data source: Prospective noninferiority trial in 360 HIV patients failing a protease inhibitor regimen.
A randomized, noninferiority trial that asked the question, "Does the addition of urodynamic testing provide significant insight or valuable alterations to treatment planning and surgical outcomes in patients with uncomplicated stress-predominant incontinence and a positive cough stress test?
Sierra-Madero noted in a report on findings from a randomized noninferiority trial.
This study was planned as a noninferiority trial for the primary endpoint with an efficacy rate estimated at 50% and a difference between miconazole Lauriad(R) 50mg Bioadhesive Buccal Tablet and miconazole gel lower than 20%.