Use of newer short to intermediate acting nondepolarizing agents
to facilitate tracheal intubation instead of succinylcholine.
The nondepolarizing agents are poorly lipophilic and do not penetrate well into fat tissue or across the blood-brain barrier.
All nondepolarizing agents have a tendency to release histamine from mast cells.
By preventing the binding of acetylcholine, the nondepolarizing agents
block the depolarizing effects of acetylcholine, thereby preventing muscle contraction.