If a patient requires intubation, a nondepolarizing agent
such as rocuronium and vecuronium is preferred.
The dose was titrated against patient's response which is followed by morphine, sodium thiopentone and nondepolarizing agents
. Anesthesia was maintained with oxygen, nitrous oxide, halothane, enflurane or isoflurane through circle system.
NMBAs are classified as depolarizing or nondepolarizing agents
. Depolarizing agents mimic the effect of acetylcholine at the neuromuscular junction, and these include succinylcholine and decamethonium.
* Use of newer short to intermediate acting nondepolarizing agents
to facilitate tracheal intubation instead of succinylcholine.
The nondepolarizing agents are poorly lipophilic and do not penetrate well into fat tissue or across the blood-brain barrier.
All nondepolarizing agents have a tendency to release histamine from mast cells.
By preventing the binding of acetylcholine, the nondepolarizing agents
block the depolarizing effects of acetylcholine, thereby preventing muscle contraction.