nondepolarizing agent

Anesthesiology An agent–eg, pancuronium, used to facilitate airway management, control alveolar ventilation, abolish motor reflexes, and provide muscle relaxation for surgery. See Pancuronium, Pipercuronium, Vecuronium. Cf Depolarizing agent.

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Use of newer short to intermediate acting nondepolarizing agents to facilitate tracheal intubation instead of succinylcholine.

Usefulness of propofol to prevent succinylcholine induced fasciculations and myalgia, a comparison with thiopentone sodium as an induction agent

The nondepolarizing agents are poorly lipophilic and do not penetrate well into fat tissue or across the blood-brain barrier.

All nondepolarizing agents have a tendency to release histamine from mast cells.

Neuromuscular blocking agents: mechanism of action, hazards, and USE in mechanical ventilation

By preventing the binding of acetylcholine, the nondepolarizing agents block the depolarizing effects of acetylcholine, thereby preventing muscle contraction.

Neuromuscular blocking agents and the physiology of the neuromuscular junction

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