nondepolarizing agent

nondepolarizing agent

Anesthesiology An agent–eg, pancuronium, used to facilitate airway management, control alveolar ventilation, abolish motor reflexes, and provide muscle relaxation for surgery. See Pancuronium, Pipercuronium, Vecuronium. Cf Depolarizing agent.
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If a patient requires intubation, a nondepolarizing agent such as rocuronium and vecuronium is preferred.
Anti-MuSK-Positive Myasthenic Crisis in a 7-Year-Old Female
The dose was titrated against patient's response which is followed by morphine, sodium thiopentone and nondepolarizing agents. Anesthesia was maintained with oxygen, nitrous oxide, halothane, enflurane or isoflurane through circle system.
MYOCARDIAL REVASCULARIZATION UTILIZING INTERNAL MAMMARY ARTERIES
The use of succinylcholine is contraindicated because of the risk of lethal hyperkalemia, and in terms of nondepolarizing agents, rocuronium is the drug of choice, provided smaller doses than usual are administered and muscle relaxation is monitored.
Epidural anesthesia for open gastrostomy in a patient with amyotrophic lateral sclerosis/Anestesia epidural para realizar gastrostomia abierta en paciente con esclerosis lateral amiotrofica
NMBAs are classified as depolarizing or nondepolarizing agents. Depolarizing agents mimic the effect of acetylcholine at the neuromuscular junction, and these include succinylcholine and decamethonium.
Use of neuromuscular blocking agents in acute respiratory distress syndrome
* Use of newer short to intermediate acting nondepolarizing agents to facilitate tracheal intubation instead of succinylcholine.
Usefulness of propofol to prevent succinylcholine induced fasciculations and myalgia, a comparison with thiopentone sodium as an induction agent
The nondepolarizing agents are poorly lipophilic and do not penetrate well into fat tissue or across the blood-brain barrier.
All nondepolarizing agents have a tendency to release histamine from mast cells.
Neuromuscular blocking agents: mechanism of action, hazards, and USE in mechanical ventilation
By preventing the binding of acetylcholine, the nondepolarizing agents block the depolarizing effects of acetylcholine, thereby preventing muscle contraction.
Neuromuscular blocking agents and the physiology of the neuromuscular junction

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