nondepolarizing agent

nondepolarizing agent

Anesthesiology An agent–eg, pancuronium, used to facilitate airway management, control alveolar ventilation, abolish motor reflexes, and provide muscle relaxation for surgery. See Pancuronium, Pipercuronium, Vecuronium. Cf Depolarizing agent.
References in periodicals archive ?
If a patient requires intubation, a nondepolarizing agent such as rocuronium and vecuronium is preferred.
The dose was titrated against patient's response which is followed by morphine, sodium thiopentone and nondepolarizing agents. Anesthesia was maintained with oxygen, nitrous oxide, halothane, enflurane or isoflurane through circle system.
The use of succinylcholine is contraindicated because of the risk of lethal hyperkalemia, and in terms of nondepolarizing agents, rocuronium is the drug of choice, provided smaller doses than usual are administered and muscle relaxation is monitored.
NMBAs are classified as depolarizing or nondepolarizing agents. Depolarizing agents mimic the effect of acetylcholine at the neuromuscular junction, and these include succinylcholine and decamethonium.
* Use of newer short to intermediate acting nondepolarizing agents to facilitate tracheal intubation instead of succinylcholine.
The nondepolarizing agents are poorly lipophilic and do not penetrate well into fat tissue or across the blood-brain barrier.
All nondepolarizing agents have a tendency to release histamine from mast cells.
By preventing the binding of acetylcholine, the nondepolarizing agents block the depolarizing effects of acetylcholine, thereby preventing muscle contraction.