noncoding RNA

noncoding RNA

RNA that does not code for a PROTEIN. Examples include rRNA, snRNA, tRNA and tmRNA.
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Table S4: classification of predicted lncRNAs into different noncoding RNA families.
Long noncoding RNA HOTAIR is associated with human cervical cancer progression.
Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis.
Others detail the positional identification of genes underlying complex traits in domestic animals, mycobacterial diseases, computational advances in multi-sequence alignment, the principles of microRNA function in vertebrate physiology and human disease, repetitive sequences in complex genomes, glycosylation disorders, annotating noncoding RNA genes, chromatin and gene expression, multistage sampling for genetic studies, and ethical and legal issues relating to biobanks.
A mutation was found in a noncoding RNA gene that the authors predicted would confer resistance to the antibiotic clindamycin, a lincosamide drug commonly administered in combination with quinine to treat pregnant women and infants for malaria in Peru.
Sato et al., "Identification of a novel noncoding RNA, MIAT, that confers risk of myocardial infarction," Journal of Human Genetics, vol.
Put simply, epigenetics is the study of changes in gene function that occur without a change in the body's genetic code, instead relying on epigenetic markers on, among others, the DNA and certain nuclear proteins to turn genes "on" and "off." Epigenetic changes also are brought about by histone modifications, as well as by the role that noncoding RNA (ncRNA) plays.
The article, "A pseudogene long noncoding RNA network regulates PTEN transcription and translation in human cells," by Per Johnsson, Amanda Ackley, Linda Vidarsdo
Teachers desiring a better understanding of noncoding RNA molecules (ncRNA) will appreciate their lengthy discussion in Chapter 10, "The Message is Not the Medium." Both long ncRNA molecules such as Xist and very short, microRNAs (miRNA) are discussed, but with specific disclaimers about how much is not yet known about their roles in gene expression or about their usefulness in treating cancer.
In their own research, the UCSF team studies molecules called long noncoding RNA (lncRNA, often pronounced as "link" RNA), which are made from DNA templates in the same way as RNA from genes.
This is driven by the X-inactivation gene (XIST), which produces a noncoding RNA that covers the entire X chromosome and essentially silences it--making it inactive and condensing it into what is termed a Barr body.
The research findings described in the press release was published in the 8th August 2013 issue of Molecular Cell under the title "The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis".