non-nucleoside reverse transcriptase inhibitor


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Related to non-nucleoside reverse transcriptase inhibitor: NRTI, nucleotide reverse transcriptase inhibitors

non-nucleoside reverse transcriptase inhibitor

n. Abbr. NNRTI
Any of a various antiviral drugs, such as delavirdine, that interfere with the activity of the enzyme reverse transcriptase, are not structurally similar to natural nucleosides, and are used chiefly to treat HIV infection.
References in periodicals archive ?
Emivirine (Coactinon), a non-nucleoside reverse transcriptase inhibitor (NNRTI) in Phase III clinical development, was studied for pharmacokinetic interactions with zidovudine/lamivudine or zidovudine/indinavir.
Masood, Anti-HIV cytotoxicity enzyme inhibition and molecular docking studies of quinoline based chalcones as potential non-nucleoside reverse transcriptase inhibitors (NNRT), Bioorg.
Its products include protease inhibitors, levetiracetam assay, topiramate assay, non-nucleoside reverse transcriptase inhibitors, gabapentin assay, lamotrigine assay, zonisamide assay, methotrexate assay, thyroxine assay, and entry inhibitor.
Both are non-nucleoside reverse transcriptase inhibitors, which block HIV viral replication.
The group conducted a study, published recently in the New England Journal of Medicine, that investigated the association of cumulative exposure to protease inhibitors and non-nucleoside reverse transcriptase inhibitors with the risk of myocardial infarction.
nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), RNA polymerase inhibitors, integrase inhibitors.

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