non-nucleoside reverse transcriptase inhibitor


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Related to non-nucleoside reverse transcriptase inhibitor: NRTI, nucleotide reverse transcriptase inhibitors

non-nucleoside reverse transcriptase inhibitor

n. Abbr. NNRTI
Any of a various antiviral drugs, such as delavirdine, that interfere with the activity of the enzyme reverse transcriptase, are not structurally similar to natural nucleosides, and are used chiefly to treat HIV infection.
References in periodicals archive ?
Non-nucleoside reverse transcriptase inhibitors and Pis are the antiretrovirals most likely to cause DDIs with antipsychotics
nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors, fusion inhibitors.
The group conducted a study, published recently in the New England Journal of Medicine, that investigated the association of cumulative exposure to protease inhibitors and non-nucleoside reverse transcriptase inhibitors with the risk of myocardial infarction.
These medications used in combination with other antiretrovirals, namely the nucleoside and non-nucleoside reverse transcriptase inhibitors, truly changed HIV into a more chronic illness.
Other studies indicate that most genetic mutations that make HIV impervious to nevirapine simultaneously give the virus resistance to related drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).
The drugs fall into three major classes: nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), which target an enzyme HIV uses known as reverse transcriptase; non-nucleoside reverse transcriptase inhibitors (NNRTIs), which also target the enzyme but work in a different way; protease inhibitors, which prevent HIV from making copies after it has entered a cell; and newest class of drugs, fusion inhibitors, which block the virus' ability to infect certain components of the immune system.
Candidates with novel properties are in development in the two major drug classes: HIV reverse transcriptase inhibitors (nucleoside and nucleotide analog reverse transcriptase inhibitors; non-nucleoside reverse transcriptase inhibitors) and HIV protease inhibitors.
The three classes include: nucleoside reverse transcriptase inhibitors (NRTIs); protease inhibitors (PIs); and the newest class, non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Protease inhibitors, non-nucleoside reverse transcriptase inhibitors and interferon-alfa will continue to lead this product group based on upward trends in the patient base and the lack of competition from conventional therapies.
* HIV non-nucleoside reverse transcriptase inhibitors like delaviridine (Rescriptor) and nevirapine (Viramune).
The Food and Drug Administration has issued an advisory against taking the supplement with protease inhibitors or non-nucleoside reverse transcriptase inhibitors. The warning comes after research published in the February 12 issue of the medical journal The Lancet showed that Saint-John's-wort, when used concurrently with the protease inhibitor indinavir (Crixivan), reduces the amount of indinavir in the bloodstream--increasing drug resistance and treatment failure.

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