Overall, 68% initiated cART after meeting the criteria in government guidelines; all were started on a regimen containing a non-nucleoside analogue
reverse transcriptase inhibitor, standard practice at the time.
Subjects were allocated into two groups according to the drug class they were using at the time of the interview, namely protease inhibitors (PI) or non-nucleoside analogue
reverse transcriptase inhibitors (NNRTI).
A second class of drugs which has recently become available is the non-nucleoside analogue
reverse transcriptase inhibitors (NNRTls).
Nevirapine is an investigational non-nucleoside analogue
reverse transcriptase inhibitor and 3TC(TM) (lamivudine) is an investigational nucleoside analogue reverse transcriptase inhibitor.
It can be inhibited either by nucleoside, nucleotide analogues or by non-nucleoside analogues
The FermaVir CMV antiviral program includes nucleoside analogues, as well as a series of non-nucleoside analogues
, which appear to have a unique mechanism of action and have been shown, in vitro, to possess potent antiviral activity and a favorable cellular toxicity profile.
Investigators reported results of a 24-week, Phase IIB, Merck-sponsored study of MK-0518 in patients with resistance to protease inhibitors, nucleoside analogues and non-nucleoside analogues