Overall, 68% initiated cART after meeting the criteria in government guidelines; all were started on a regimen containing a non-nucleoside analogue
reverse transcriptase inhibitor, standard practice at the time.
Traditional antiretrovirals such as nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside analogue
reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) suppress HIV by interfering with various steps in the process of infection inside the host cell.
The approval reflects current HIV treatment guidelines, which recommend initiating therapy with two nucleoside analogues plus a protease inhibitor or the non-nucleoside analogue
Nevirapine is an investigational non-nucleoside analogue
reverse transcriptase inhibitor and 3TC(TM) (lamivudine) is an investigational nucleoside analogue reverse transcriptase inhibitor.
Investigators reported results of a 24-week, Phase II, Merck-sponsored study of MK-0518 in treatment-experienced patients with resistance to protease inhibitors, nucleoside analogues and non-nucleoside analogues
The FermaVir CMV antiviral program includes nucleoside analogues, as well as a series of non-nucleoside analogues
, which appear to have a unique mechanism of action and have been shown, in vitro, to possess potent antiviral activity and a favorable cellular toxicity profile.
Investigators reported results of a 24-week, Phase IIB, Merck-sponsored study of MK-0518 in patients with resistance to protease inhibitors, nucleoside analogues and non-nucleoside analogues
The ongoing clinical development program with the soft gelatin capsule formulation includes studying the new formulation in combination with other protease inhibitors, non-nucleoside analogues
and additional nucleoside analogues.