In a joint crowdsourcing approach, Boehringer Ingelheim and BioMed X are inviting early career neuroscientists from leading academic institutions world-wide to submit original project proposals that explore the complex circuit biology at the interface between projection neurons, interneurons and non-neuronal
cells for the generation of novel therapeutic concepts.
In contrast to mouse vRGs, which produce 10 to 100 daughter cells during brain development, a single human oRG can produce thousands of daughter neurons, as well as glial cells non-neuronal
brain cells increasingly recognized as being responsible for a broad array of maintenance functions in the brain.
Glial cells, sometimes called neuroglia or simply glia, are non-neuronal
cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain and peripheral nervous system.
To test the theory, Horvath and his team selectively knocked out leptin receptors in the adult non-neuronal
glial cells of mice.
GluRs are the predominant excitatory neurotransmitter receptors in the mammalian brain located primarily on the membranes of neuronal cells however recent findings have demonstrated expression of functional GluRs in non-neuronal
peripheral cells such as skin, placenta, and colon.
Now researchers have shown that changes in one type of non-neuronal
brain cells, called microglia, underlie the depressive symptoms brought on by exposure to chronic stress.
The text is divided into three parts: initiation and early direction of the central and peripheral nervous systems, diversification of neuronal function, and development of non-neuronal
cells, with a focus on the role of glia.
Whereas nerve growth factor was described first in the chronological order, BDNF is the best known member of the group regarding their functions in the non-neuronal
Richard Sando III, a graduate student at the TSRI Kellogg School of Science and Technology, a member of the Maximov lab and the first author of this study, noted the team become interested in class IIa histone deacetylases (HDACs), which include HDAC4, in part because they have been implicated in regulation of transcription of non-neuronal
In recent years, several studies have focused on the expression and biological role of the neuronal and non-neuronal
cholinergic system in inflammatory processes and immune system (9).
11,12] The high density of muscarinic receptors expressed on urothelium can not only mediate release of urothelium-derived inhibitory factor, but these receptors, along with the innate mechanism of non-neuronal
ACh release operating at the urothelium, can become an alternative site of action for antimuscarinic drugs.
of Florence, Italy) explains in her introduction, the 22 chapters of this book "have evolved around the concept that the first sensory synapse between the central terminals of primary sensory neurons and dorsal horn neurons in the spinal cord is plastic and modifiable" by neuronal and non-neuronal
regulators, promising the identification of new targets for the treatment of chronic pain.