non-hemolytic transfusion reaction

non-hemolytic transfusion reaction

Transfusion medicine Immune reactivity to homologous WBCs in a previously sensitized blood product recipient, which occurs in 0.5–5.0% of all transfusions, and in up to 50% of Pts with βº thalassemia Prevention NTRs are minimized by using leukocyte-depleted blood products. See Leukocyte reduction.
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As described by Tobian, King, and Ness (2007), the practice of premedicating clients with acetaminophen and diphenhydramine prior to transfusion originated in the 1950s when several studies concluded that administration of these agents decreased the rate of allergic transfusion reactions (ATRs) and febrile non-hemolytic transfusion reactions (FNHTRs), two classes of transfusion reactions.
First of all, for preventing TT- CMV, based on the data of this study, but also for preventing febrile non-hemolytic transfusion reactions in multi-transfused patient populations (major beta thalassemia patients).
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