non-alcoholic fatty liver disease


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non-alcoholic fatty liver disease

A fatty liver lacking histologic features typically associated with alcohol abuse, which primarily affects overweight women. With time, patients develop portal changes such as interface hepatitis, increased portal inflammation and fibrosis, and autoantibodies.
 
Risk factors
Diabetes, obesity, hypertension, gallstones, hyperlipidaemia, hypertriglyceridaemia.

Pathogenesis
Uncertain; possibly oxidative stress and lack of antioxidants.

Non-alcoholic fatty liver disease types
• Steatosis;
• Steatosis with inflammation;
• Non-alcoholic steatohepatitis (NASH);
• Cirrhosis.
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References in periodicals archive ?
BASF Corporation is introducing Hepaxa, a product that can help tens of millions of patients manage Non-Alcoholic Fatty Liver Disease (NAFLD), one of the most common forms of chronic liver disease.
ARRIVE, a Phase IIa, investigator initiated clinical trial conducted at the University of California San Diego was a randomised, double-blinded, placebo-controlled, 12 weeks, proof-of-concept study that evaluated the safety and efficacy of Aramchol at 600mg/day versus placebo in 50 patients with HIV-associated lipodystrophy and non-alcoholic fatty liver disease, or NAFLD.
An article published in 2010 in The New England Journal of Medicine indicated that people with non-alcoholic fatty liver disease are more likely than those without it to have build-ups of cholesterol-filled plaque in their arteries, the blood vessels that supply the heart.
ARRIVE, a Phase IIa, investigator initiated clinical trial conducted at the University of California San Diego by Professor Rohit Loomba was a randomized, double-blinded, placebo-controlled, 12 weeks, proof-of-concept study that evaluated the safety and efficacy of Aramchol at 600mg/day versus placebo in 50 patients with HIV-associated lipodystrophy and non-alcoholic fatty liver disease, or NAFLD.
The findings are significant, researchers said, because liver problems such as non-alcoholic fatty liver disease are surging in the US, affecting 10-35 percent of adults and an increasing number of children.
Keywords: Lipid profile, Non-alcoholic fatty liver disease (NAFLD), NonHDL cholesterol, Ultrasonography.
Coffee drinkers also have a 29% lower risk of non-alcoholic fatty liver disease, a 27% lower risk of liver fibrosis and a 39% lower risk of liver cirrhosis.
According to a previous study, a diet high in animal protein is associated with a higher risk of non-alcoholic fatty liver disease, a condition in which fat builds up in the liver, in overweight people.
5] It is well established that patients of OSAS exhibit various metabolic abnormalities like insulin resistance, systemic hypertension, dyslipidemia, obesity and oxidative stress including non-alcoholic fatty liver disease (NAFLD).
According to Dr Adi Mor, ChemomAb CEO, the current funding round will enable the company to move forward with its clinical programme for monoclonal antibody, while examining its efficacy and safety profile in patients with non-alcoholic fatty liver disease (NASH) as well as support its continued development for additional fibrotic orphan indications and test its effectiveness in these diseases.
Their aim is to develop better ways for testing people who could be severely affected by non-alcoholic fatty liver disease (NAFLD) - a condition caused by a build-up of fat in the liver.

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