non-alcoholic fatty liver disease


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non-alcoholic fatty liver disease

A fatty liver lacking histologic features typically associated with alcohol abuse, which primarily affects overweight women. With time, patients develop portal changes such as interface hepatitis, increased portal inflammation and fibrosis, and autoantibodies.
 
Risk factors
Diabetes, obesity, hypertension, gallstones, hyperlipidaemia, hypertriglyceridaemia.

Pathogenesis
Uncertain; possibly oxidative stress and lack of antioxidants.

Non-alcoholic fatty liver disease types
• Steatosis;
• Steatosis with inflammation;
• Non-alcoholic steatohepatitis (NASH);
• Cirrhosis.
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References in periodicals archive ?
The technology is currently being used to assess primary endpoints in clinical trials for investigational therapies to treat non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
A liver burdened with accumulated fat is referred to clinically as non-alcoholic fatty liver disease (NAFLD).
Objective: Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing clinical problem, affecting a third of the European population.
Despite its name, non-alcoholic fatty liver disease isn't solely caused by eating too much fat.
TEHRAN (FNA)- A daily sugar-sweetened beverage habit may increase the risk for non-alcoholic fatty liver disease (NAFLD), researchers report.
Lee Penaluna, 32, owner of Penaluna's Fish and Chip Shop in Hirwaun, was told he would not reach the age of 40 if he continued to put on weight, after being diagnosed with non-alcoholic fatty liver disease.
PENNY Anderson knows first-hand what it's like to suffer from non-alcoholic fatty liver disease.
Washington, April 13 ( ANI ): Scientists have identified a genetic variant associated with non-alcoholic fatty liver disease (NAFLD) in British children while investigating link between low vitamin D status and the disease.
Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity.
This disorder is a disease, like sickle cell anemia and thalassemia, in which chronic blood loss requires frequent blood transfusions (though beta minor thalassemia has been associated with hemosiderin deposits in the liver in patients with non-alcoholic fatty liver disease independent of any transfusions).
2) Left unchecked, toxic overload can lead to conditions ranging from cirrhosis and hepatitis to non-alcoholic fatty liver disease and even cancer.
Having too much fat stored in the liver is known as non-alcoholic fatty liver disease.

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