A team from University College London interviewed the families of 48 people with either Alzheimer's or non-Alzheimer's dementia
about any changes they had noticed in their relative's sense of humour.
patients living in a residential care facility who exercised for 45 minutes two or three times a week for four months were less likely to need assistance with activities of daily living, such as going to the bathroom and walking, than patients who engaged in group activities such as reading aloud and conversing for the same frequency and duration.
The dementia fighters have given some attention to non-Alzheimer's dementia
for humanitarian reasons, and because learning more about non-Alzheimer's dementia
may give researchers ideas about how to prevent and treat Alzheimer's disease.
A total of 632 (9 percent) participants developed dementia over the 8 subsequent years of follow-up, among them 284 probable AD and 228 possible AD, and the remaining 120 non-Alzheimer's dementia
* The results of this study may not be applicable to primary-care settings, to individuals whose depression is severe, to non-Alzheimer's dementia
, or even to other antidepressant drugs other than sertraline and mirtazapine.
At UCSF's MAC, researchers required video documentation of elusive symptoms to help standardize the diagnosis of non-Alzheimer's dementia
. In word processing versus typing, one space after the end of a sentence is protocol.
Patients who had Alzheimer's scored an average of 33 out of 50, while patients with non-Alzheimer's dementia
scored an average of 39 out of 50.
During follow-up (median duration, 6.6 years), there were 125 newly diagnosed cases of dementia, 70 of them cases of Alzheimer's and 55 cases of non-Alzheimer's dementia
(47 of which involved vascular dementia and eight of which involved other types of dementia).
And the inclusion of patients with "mild Alzheimer's," who probably had non-Alzheimer's dementia
, may have tainted the study pool and subsequent results of both trials.
Four with diagnoses of very mild Alzheimer's who were PIB-negative and had high CSF A[[beta].sub.42] have had their diagnoses changed to no dementia or non-Alzheimer's dementia
. "High CSF A[[beta].sub.42] and cortical PIB-negativity may be useful for a differential diagnosis, identifying possible Alzheimer's misdiagnoses in the very early stages."
Four who had a diagnosis of very mild Alzheimer's at the time of testing, but who were PIB-negative and had high CSF A[[beta].sub.42] have had their diagnoses changed to either "no dementia" or "non-Alzheimer's dementia
." "This seems to say that high CSF A[[beta].sub.42] and cortical PIB-negativity may be useful for a differential diagnosis, identifying possible Alzheimer's misdiagnoses in the very early stages."
Knopman also pointed out that the lack of baseline amyloid PET imaging almost certainly means that there were patients with other, non-Alzheimer's dementias
in the trial.