non-A, non-B hepatitis


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non-A, non-B hep·a·ti·tis

hepatitis caused by any number of infectious agents not detectable by methods that reveal the presence of hepatitis viruses A and B.
Synonym(s): NANB hepatitis

non-A, non-B hepatitis

(nŏn-ā′ nŏn-bē′)
n.
Any of various forms of hepatitis, including hepatitis C and hepatitis E, caused by a virus that is antigenically different from hepatitis viruses A and B.

non-A, non-B hepatitis

A group of hepatitides which are the major cause of transfusion-related hepatitis Incidence 7/105/yr–US Risk factors 42% IV drug abuse, 40% unknown risk factors, 6% sexual contact, 6% blood transfusion, 3% household contact, 2% health care professional; of the ±150,000 new cases/yr–US, 30-50% become chronic carriers–20% of these develop cirrhosis; NANBH may also be enteric–parenteral; NANBH is most commonly due to HCV and enteric NANBH to HEV Management IFN-α2b results in significant histologic reversal and serum ALA response Prognosis No ↑ in overall mortality with chronic NANBH, but ↑ liver-related deaths. See Hepatitis.

non-A, non-B hep·a·ti·tis

(NANB) (hep'ă-tī'tis)
Hepatitis caused by any number of infectious agents not detectable by methods that reveal the presence of hepatitis viruses A and B.
References in periodicals archive ?
Aetiological association of virus-like particle with enterically transmitted non-A, non-B hepatitis.
Common aetiological agent for epidemic and sporadic non-A, non-B hepatitis.
Epidemic transmission of enterically transmitted non-A, non-B hepatitis in Mexico, 1986-1987.
Hepatitis E virus: the main cause of enterically transmitted non-A, non-B hepatitis.
Although transfusion-transmitted cases of non-A, non-B hepatitis were relatively easy to document, sporadic (community-acquired) cases predominated.
The test allows investigators to test the theory that non-A, non-B hepatitis is caused by a single agent, not by multiple ones.
Houghton is a director of non-A, non-B hepatitis research for Chiron Corporation, Emeryville.
Thus, it appears that hepatitis C virus is a major cause of community-acquired non-A, non-B hepatitis as well as post-transfusion non-A, non-B hepatitis," the researchers write in the April 21 SCIENCE.
The test gave a positive result in six out of seven blood samples known to cause non-A, non-B hepatitis in chimpanzees and a negative result in all seven control samples, demonstrating that it detects antibody in infectious samples, Houghton says.
blood-transfusion recipients contract non-A, non-B hepatitis, a poorly defined ailment that is diagnosed when lab tests indicate biochemical signs of liver injury but no signs of hepatitis in the blood.
He says the percentage of positive results varies with the population tested, adding he expects the screening test now in development to detect at least 80 percent of donated blood units that are infected with non-A, non-B hepatitis viruses.
Chiron scientists characterized HCV in 1987 following five years of research into the possible cause of what then was termed non-A, non-B hepatitis, which had eluded dozens of groups working in larger companies and institutions.