non-A, non-B hepatitis


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non-A, non-B hep·a·ti·tis

hepatitis caused by any number of infectious agents not detectable by methods that reveal the presence of hepatitis viruses A and B.
Synonym(s): NANB hepatitis

non-A, non-B hepatitis

(nŏn-ā′ nŏn-bē′)
n.
Any of various forms of hepatitis, including hepatitis C and hepatitis E, caused by a virus that is antigenically different from hepatitis viruses A and B.

non-A, non-B hepatitis

A group of hepatitides which are the major cause of transfusion-related hepatitis Incidence 7/105/yr–US Risk factors 42% IV drug abuse, 40% unknown risk factors, 6% sexual contact, 6% blood transfusion, 3% household contact, 2% health care professional; of the ±150,000 new cases/yr–US, 30-50% become chronic carriers–20% of these develop cirrhosis; NANBH may also be enteric–parenteral; NANBH is most commonly due to HCV and enteric NANBH to HEV Management IFN-α2b results in significant histologic reversal and serum ALA response Prognosis No ↑ in overall mortality with chronic NANBH, but ↑ liver-related deaths. See Hepatitis.

non-A, non-B hep·a·ti·tis

(NANB) (hep'ă-tī'tis)
Hepatitis caused by any number of infectious agents not detectable by methods that reveal the presence of hepatitis viruses A and B.
References in periodicals archive ?
The test allows investigators to test the theory that non-A, non-B hepatitis is caused by a single agent, not by multiple ones.
This "library" of bacteriophage-expressed polypeptides was subsequently screened against the serum of a patient with documented chronic non-A, non-B hepatitis. Investigators hoped to detect in the index patient's serum the presence of antibody to possible viral polypeptides.
Harvey Alter, M.D., and colleagues at the NIH Clinical Center ultimately provided the link between the bacteriophage-expressed polypeptide, the antibody that reacted to it, and non-A, non-B hepatitis. Dr.
The test gave a positive result in six out of seven blood samples known to cause non-A, non-B hepatitis in chimpanzees and a negative result in all seven control samples, demonstrating that it detects antibody in infectious samples, Houghton says.
Furthermore use of the test should shed light on whether other agents can cause non-A, non-B hepatitis, Houghton says.
In a previous study on the Italian island of Sardinia -- where hepatitis B infection is 30 times more common than in the United States and so is easier to study -- Vyas and co-workers Eliana Lai and Annalena Figus found that one-third of chronic liver disease victims diagnosed as having non-A, non-B hepatitis carried mutant forms of hepatitis B undetectable by standard tests for the virus.
High levels of ALT indicate liver injury and provide today's sole criterion for diagnosing non-A, non-B hepatitis, Vyas says.
Chronic hepatitis develops in 30 to 50 percent of those with blood-borne non-A, non-B hepatitis, and 20 percent of chronic carriers go on to develop cirrhosis.