NOG

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NOG

A gene on chromosome 17q22 that encodes noggin, a protein that inhibits TGF-beta signal transduction by binding to TGF-beta family ligands, preventing them from binding to their cognate receptors. Noggin plays a key role in neural induction by inhibiting BMP4 and other TGF-beta signalling inhibitors (e.g., chordin and follistatin), and it is required for cartilage morphogenesis and joint formation.
References in periodicals archive ?
Compared with blank group, preliminary experimental results showed the best genes for extracting RNA primers at annealing temperature and amount of template after noggin gene interference.
Cell morphology was presented during induction progress especially at days 1, 5, 10, and 12 with Noggin and SB431542 added to human ES cells (Figure 2(b)).
The human NOGGIN gene (NOG), with a length of 1.9 kb is located on chromosome 17q22 (NOG; MIM # 602991).
Types of failure modes were observed in these walls like elastic local buckling of stud, screw saliency, wall concrete demolition, concrete demolition against noggin, separating concrete from side stud, the creation of diagonal and horizontal cracks in concrete.
Keywords: Cerberus protein, Chordin, FGF8 protein, Follistatin, Noggin protein, Somites
Recombinant BMP2, BMP4, and noggin were purchased from Peprotech (NJ, USA).
The researchers then used a known BMP inhibitor called Noggin, and found that Noggin blocked the mesenchymal stem cells from triggering this cancer stem cell growth.
They pitched the idea of a quirky two-dimensional character named "Noggin" who would serve as the voice or "alter-ego" of the bank.
'Come on, why don't you rest your noggin on my toboggan?' 'You're a poet' said Sheep.
Then, the little light came on over his noggin and he reached for his trusty Roscoe ...
We told how auctioneer John Anderson made the amazing find of titles ranging from Captain Pugwash and Noggin the Nog to Batman and Spiderman when clearing out a house in Fenham, Newcastle.
The design is so completely simple and effective it's a wonder it hasn't been thought of before, the hat is one size fits most and if you have a bald head like me it does a decent job of keeping your noggin warm.