Lentigo maligna melanoma, which typically arises in chronically sun-damaged skin, shows differences in its molecular pathology, when compared to other subtypes such as superficial spreading or nodular melanoma
NM = nodular melanoma
, LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, ALM = acral lentiginous melanoma, DM = desmoplastic melanoma.
If the theory proves correct, "it reveals a way we can prevent development of nodular melanoma
and by doing so, save lives," he added.
Misdiagnosis of nodular melanoma
as nevus by a clinician or pathologist.
But these criteria do not apply to nodular melanomas
, which typically are round, elevated, red or pink, and uniform in color throughout.
Conventional pagetoid or nodular melanoma
are most commonly observed in small CMN (Figure 3, a), whereas melanomas developing in large CMN are dermal and composed of epithelioid, spindle, or small round cells.
misdiagnosed as a nevus by the pathologist.
2,5,9) For example, there is some evidence that nodular melanoma
and acral lentiginous melanoma have a worse prognosis than other subtypes.
Friedman and his group proposed adding the E, for evolution or any change in a nevus, in 2004, in part to improve the criteria for detecting melanomas with a diameter less than 6 mm, nodular melanomas
, and the 10% of melanomas that do not meet A, B, C, or D.
Pan-nuclear staining is also observed in a subset of neoplastic cells in superficial spreading melanomas and nodular melanomas
, but not to the extent seen in the setting of lentiginous melanomas.
Shore's experience seems unusual in that he didn't encounter any of the feared nodular melanomas
that are so fast growing they have defied efforts to improve outcome through early detection.
21) Consistently, FISH results are abnormal in almost all metastatic melanomas and aggressive nodular melanomas
and in only 50% of more-indolent desmoplastic melanoma.