nodular melanoma

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nod·u·lar mel·a·no·ma

primary cutaneous melanoma that presents as rapidly growing smoothly spheroid or ulcerated nodules in which tumor cells microscopically invade the dermis beneath all the lateral epidermal margins of involvement.

nodular melanoma

a melanoma that is nodular and uniformly pigmented, usually bluish-black, and sometimes surrounded by an irregular halo of pale, unpigmented skin. The lesion is always raised and may be dome-shaped or polypoid. Most often the tumor is found in middle-aged adults and occurs in 10% to 15% of patients with melanoma. See also lentigo maligna melanoma, superficial spreading melanoma.

Nodular malignant melanoma

nodular melanoma

The most aggressive of all melanomas, which arises de novo in the so-called vertical growth phase—i.e., it is invasive ab initio. Nodular melanomas comprise 15% of all melanomas.

Prognosis
50% average 5-year survival.

nodular melanoma

A melanoma that comprises 15% of melanomas; NM is similar clinically to superficial spreading melanoma; 50% average 5-yr survival. See Melanoma.

nodular melanoma

nodular hypopigmented or amelanotic melanoma, characterized by rapid vertical growth

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References in periodicals archive ?

Lentigo maligna melanoma, which typically arises in chronically sun-damaged skin, shows differences in its molecular pathology, when compared to other subtypes such as superficial spreading or nodular melanoma.

Molecular Pathology of Skin Neoplasms of the Head and Neck

NM = nodular melanoma, LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, ALM = acral lentiginous melanoma, DM = desmoplastic melanoma.

Lifetime risks of cutaneous melanoma by histological subtype and race/ethnicity in the United States

If the theory proves correct, "it reveals a way we can prevent development of nodular melanoma and by doing so, save lives," he added.

Can serial screening avert melanoma?

Misdiagnosis of nodular melanoma as nevus by a clinician or pathologist.

Vigilance key to avoid missing melanomas

But these criteria do not apply to nodular melanomas, which typically are round, elevated, red or pink, and uniform in color throughout.

Don't rely on "ABCD" for nodular melanoma

Conventional pagetoid or nodular melanoma are most commonly observed in small CMN (Figure 3, a), whereas melanomas developing in large CMN are dermal and composed of epithelioid, spindle, or small round cells.

Melanoma in children

Nodular melanoma misdiagnosed as a nevus by the pathologist.

Melanoma misdiagnosis often prompts lawsuits

2,5,9) For example, there is some evidence that nodular melanoma and acral lentiginous melanoma have a worse prognosis than other subtypes.

Malignant Melanoma: an update. (Special article)

Friedman and his group proposed adding the E, for evolution or any change in a nevus, in 2004, in part to improve the criteria for detecting melanomas with a diameter less than 6 mm, nodular melanomas, and the 10% of melanomas that do not meet A, B, C, or D.

Change in color can be earliest sign of melanoma

Pan-nuclear staining is also observed in a subset of neoplastic cells in superficial spreading melanomas and nodular melanomas, but not to the extent seen in the setting of lentiginous melanomas.

Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins

Shore's experience seems unusual in that he didn't encounter any of the feared nodular melanomas that are so fast growing they have defied efforts to improve outcome through early detection.

Melanoma screen program boasts 100% survival

21) Consistently, FISH results are abnormal in almost all metastatic melanomas and aggressive nodular melanomas and in only 50% of more-indolent desmoplastic melanoma.

Correlation between histologic assessment and fluorescence in situ hybridization using MelanoSITE in evaluation of histologically ambiguous melanocytic lesions