nodular melanoma


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nod·u·lar mel·a·no·ma

primary cutaneous melanoma that presents as rapidly growing smoothly spheroid or ulcerated nodules in which tumor cells microscopically invade the dermis beneath all the lateral epidermal margins of involvement.

nodular melanoma

a melanoma that is nodular and uniformly pigmented, usually bluish-black, and sometimes surrounded by an irregular halo of pale, unpigmented skin. The lesion is always raised and may be dome-shaped or polypoid. Most often the tumor is found in middle-aged adults and occurs in 10% to 15% of patients with melanoma. See also lentigo maligna melanoma, superficial spreading melanoma.
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Nodular malignant melanoma

nodular melanoma

The most aggressive of all melanomas, which arises de novo in the so-called vertical growth phase—i.e., it is invasive ab initio. Nodular melanomas comprise 15% of all melanomas.

Prognosis
50% average 5-year survival.

nodular melanoma

A melanoma that comprises 15% of melanomas; NM is similar clinically to superficial spreading melanoma; 50% average 5-yr survival. See Melanoma.

nodular melanoma

nodular hypopigmented or amelanotic melanoma, characterized by rapid vertical growth
References in periodicals archive ?
Lentigo maligna melanoma, which typically arises in chronically sun-damaged skin, shows differences in its molecular pathology, when compared to other subtypes such as superficial spreading or nodular melanoma.
NM = nodular melanoma, LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, ALM = acral lentiginous melanoma, DM = desmoplastic melanoma.
If the theory proves correct, "it reveals a way we can prevent development of nodular melanoma and by doing so, save lives," he added.
Misdiagnosis of nodular melanoma as nevus by a clinician or pathologist.
But these criteria do not apply to nodular melanomas, which typically are round, elevated, red or pink, and uniform in color throughout.
Conventional pagetoid or nodular melanoma are most commonly observed in small CMN (Figure 3, a), whereas melanomas developing in large CMN are dermal and composed of epithelioid, spindle, or small round cells.
Nodular melanoma misdiagnosed as a nevus by the pathologist.
2,5,9) For example, there is some evidence that nodular melanoma and acral lentiginous melanoma have a worse prognosis than other subtypes.
Friedman and his group proposed adding the E, for evolution or any change in a nevus, in 2004, in part to improve the criteria for detecting melanomas with a diameter less than 6 mm, nodular melanomas, and the 10% of melanomas that do not meet A, B, C, or D.
Pan-nuclear staining is also observed in a subset of neoplastic cells in superficial spreading melanomas and nodular melanomas, but not to the extent seen in the setting of lentiginous melanomas.
Shore's experience seems unusual in that he didn't encounter any of the feared nodular melanomas that are so fast growing they have defied efforts to improve outcome through early detection.
21) Consistently, FISH results are abnormal in almost all metastatic melanomas and aggressive nodular melanomas and in only 50% of more-indolent desmoplastic melanoma.

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