nodular lymphoid hyperplasia

nodular lymphoid hyperplasia

A bone marrow finding variously defined as:
(1) The presence of ≥ 4 normal lymphoid aggregates (average size 0.3 mm) in any low-power (40x) light microscopic field; or
(2) An enlarged (> 0.6 mm) lymphoid nodule.

Nodular lymphoid hyperplasia occurs in up to 60% of bone marrow specimens, at autopsy and, when extreme, mimics a lymphoproliferative process.
 
Associations
ITP, rheumatoid arthritis, cirrhosis, hyperthyroidism, anaemia (autoimmune, haemolytic, drug-related, iron deficiency, and refractory), macroglobulinaemia, Hodgkin lymphoma, large-cell lymphoma, and cryoglobulinaemia.
 
DiffDx
CLL, primary small-cell lymphoma, well-differentiated lymphoma.

nodular lymphoid hyperplasia (small intestine)

The presence in younger (< age 30) adults of multiple submucosal lymphoid aggregates with prominent germinal centres, most common in the small intestine, but which also occurs in the stomach and the large intestine. In children, NLH may be nonspecific; in adults it is usually pathological and associated with defects in humoral immunity—e.g., selective IgA deficiency, common variable immune deficiency/ hypogammagolulineamia, HIV infection. It may occur in absence of humoral immune defects in patients with giardiasis.

Clinical findings
Range from mild GI discomfort (in IgA deficiency) to severe malabsorption, chronic diarrhoea, recurrent bacterial infections with sinusitis, bronchitis, bronchiectasis, pneumonia (in CVID). Recurrent infections seen in NLH Campylobacoccidiangardiasis, cryptosporidiosis.
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References in periodicals archive ?
Nodular lymphoid hyperplasia of the lung: a clinicopathologic study of 14 cases.
The significant findings included ulcers and erosions in 36%, erythema in 22%, aphthae in 17%, nodular lymphoid hyperplasia in 20%, and other features in 5%.
This article will review the thoracic manifestations of immunoglobulin (Ig) G4-related sclerosing disease and summarize the concepts of follicular bronchiolitis, lymphocytic interstitial pneumonitis (LIP), and nodular lymphoid hyperplasia.
Follicular bronchiolitis should be distinguished from LIP, nodular lymphoid hyperplasia, and low-grade BALT lymphoma.
Nodular lymphoid hyperplasia is easily distinguished from follicular bronchiolitis by its radiographic and histologic features.
Common variable immunodeficiency syndrome and nodular lymphoid hyperplasia in the small intestine.
Nodular lymphoid hyperplasia of the colon in adults: is it common?
This review article will focus on the most common lesions encountered in the thoracic cavity, including organizing pneumonia, nodular lymphoid hyperplasia, apical scar, round atelectasis, and sclerosing (fibrosing) mediastinitis and hyalinizing granuloma.
Pulmonary nodular lymphoid hyperplasia (NLH), a term first coined by Kradin and Mark, (33) refers to 1 or more nodules or localized pulmonary infiltrates consisting of a reactive lymphoid proliferation.
In this patient, colonoscopy showed diffuse nodular lymphoid hyperplasia of the large intestine that gave rise to a striking endoscopic appearance mimicking generalized colonic polyposis.
4] In this case, the distribution of the melanosis pigment as shown in the endoscopic photograph (Figure 1) emphasizes the diffuse nature of the patient's diffuse nodular lymphoid hyperplasia of the colon and rectum.

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