node-negative

node-negative

Oncology adjective Referring to a cancer that has not spread to regional lymph nodes. See Axillary tail.
References in periodicals archive ?
These validation studies show that Prosigna identifies a clinically relevant low-risk subgroup among both node-negative and node-positive patients with 1-3 involved lymph nodes.
We found that use of the assay was largely restricted to the populations for which it was initially approved in 2005, namely women with estrogen receptor-positive, lymph node-negative, stage I or II breast cancer," the investigators said (JAMA Oncol.
Using a 70-gene signature screening tool for adjuvant chemotherapy decisions cost significantly more than did other methods, including giving chemotherapy to all patients, but did not confer any additional benefits in survival or quality of life, for women with node-negative breast cancer.
The Oncotype DX Breast Cancer Test is appropriate for recently diagnosed women with Stage I or II node-negative, oestrogen-receptor-positive, HER2 negative, invasive breast cancer; and postmenopausal women with node-positive, hormone-receptor-positive, HER2 negative, invasive breast cancer.
However, 30% of node-negative patients still may develop recurrences by 10 years.
Another study by de Boer et al (24) involved 2707 patients: 856 with node-negative disease and no adjuvant therapy, 856 with ITC or micrometastasis and no adjuvant therapy, and 995 with ITC or micrometastasis with adjuvant therapy.
Patients with MM and ITCs, at 5-years follow-up, had similar survival to node-negative patients, although a significant number of patients with MM received chemotherapy.
Recent publication of the survival analysis from the NSABP B-32 trial provides level- one evidence confirming findings from numerous retrospective cohort studies demonstrating the oncological equivalence of sentinel node biopsy (SNB) to axillary clearance in clinically node-negative breast cancer [1], This and other studies including the ALMANAC Trial [2], have previously confirmed reduced morbidity and improved patient-reported outcomes with SNB.
The trial followed 1,234 women who had node-negative breast cancer with tumors smaller than 5 cm and negative margins after breast-conserving surgery.
Although the absolute limits of lymphadectomy at the time of surgery have not been precisely defined, there is a growing body of evidence to suggest that an extended lymph node dissection may be beneficial for staging and survival in both node-negative and -positive bladder cancer patients.