nodal disease

nodal disease

A cancer that has extended into lymph nodes and is thus not localised.
References in periodicals archive ?
Sentinel lymph node (SLN) biopsy will accurately identify nodal metastases in 97% of women with nodal disease.
This study and a recent meta-analysis [28] emphasise the major role of NACT to reduce ALND in patients with initial nodal disease and the feasibility of the procedure.
Twenty men with metastatic prostate cancer, five with extra-pelvic lymph nodal disease and 15 with bone with or without nodal disease, were treated with androgen deprivation therapy (ADT), radical surgery that included a retroperitoneal lymph node dissection as needed, and radiation therapy to visible metastatic lesions in bone.
Plus, the terminology for nodal disease has changed.
2] However, treatment may be required for patients with extranodal RDD involving vital organs such as orbits, or those with nodal disease, causing life-threatening complications.
In a study utilizing the Surveillance, Epidemiology, and End Results Program (SEER) database, Smith et al identified male sex, a primary site on the lip, tumor extension beyond the dermis, confirmed nodal disease, a lack of lymph node evaluation, and distant metastasis as independent prognostic factors for MCC of the head and neck.
Today, patients with breast carcinoma have smaller tumors and lower nodal disease burden compared with historical series, and most are treated with adjuvant systemic therapy, which is now recognized as improving local as well as systemic control.
Defining any hematogenous spread or nodal disease above or at L5 as distant metastases (DM) and any pelvic soft tissue or nodal disease below L5 as pelvic recurrence (PR), the eventual clinical status was categorized as: 1) no tumour recurrence; 2) pelvic recurrence only (with date); 3) distant metastases only (with date); 4) distant metastases and pelvic recurrence regardless of whether identified simultaneously or not; and 5) pelvic tumour status unknown.
Tumours with pathological T3 (pT3), pT4, tumour thickness >4mm, close margins, lymphovascular invasion (LVI), perineural invasion (PNI) and/or N2/N3 nodal disease were subjected to post-operative radiation (PORT ).
Later these criteria were relaxed to allow for contiguous involvement of organs (liver spleen) and distal nodal disease provided that the extanodal site was the presenting site.
However, it also occurs as a result of drugs that slow AV node conduction (beta blockers or calcium channel blockers) or in persons with intrinsic AV nodal disease, myocarditis, acute inferior myocardial infarction or ischemia, and after cardiac surgery (Sauer, 2013).
The axillary nodes were seldom evaluated in the past as potential morbidity from full axillary nodal dissection (ALND), where the level I and II nodes are removed, and even from axillary sampling, outweighed the possibility of finding nodal disease that would change treatment recommendations 3].