In a planned extension of this trial, the authors examined whether the pattern of glycemic control, tolerability, and risk of nocturnal hypoglycemia
was achieved with continued use of Glar-300 for a further 6 mo interval of randomized but less intensively supervised treatment.
(2) The risk of hypoglycemia was statistically significantly decreased in the IDeg treatment group as compared to that in the IGlar treatment group of patients with T2DM, as was nocturnal hypoglycemia
. While in patients with T1DM, the IDeg treatment was associated with a lower risk of nocturnal hypoglycemia
, but not associated with a lower risk of overall hypoglycemia.
In contrast, patients with moderate-capacity, low-affinity IAs may suffer from moderate nocturnal hypoglycemia
. Patients with high-capacity, low-affinity IAs may suffer severe daytime hyperglycemia and nighttime hypoglycemia and may require treatment with immunosuppressants (5).
occurs when blood glucose levels fall below the target physiological level (4 mmol/l or 72 mg/dl) at night time.
Hershey et al., "Impact of nocturnal hypoglycemia
on hypoglycemic cognitive dysfunction in type 1 diabetes," Diabetes, vol.
A prospective metaanalysis of phase Ma trials comparing insulin degludec with insulin glargine showed that type 1 diabetes patients who were on degludec had a statistically significant 17% lower rate of nocturnal hypoglycemia
across the entire treatment period and a 25% lower rate over the maintenance period (16 weeks onward), compared with those on glargine (Diabetes Obes.
In fact, nocturnal hypoglycemia
is the main barrier to reaching glycemic targets," she noted.
While improvements in HbA1c were comparable, the group who switched to insulin glargine showed a 25% decrease in the rate of nocturnal hypoglycemia
(26.5% versus 35.5%, p = 0.0136).
However this type of activity may increase the risk of nocturnal hypoglycemia
He worried less about nocturnal hypoglycemia
when he started dialysis over five years ago because he was married to a nurse.
It can be used to identify nocturnal hypoglycemia
or hyperglycemia after meals, allowing for therapy adjustments to improve glucose control thus lowering the risk of diabetes complications such as blindness, kidney failure, impotence, amputation and heart disease.
was defined as symptoms of hypoglycemia occurring after the last insulin injection and before the morning insulin dose.