In a planned extension of this trial, the authors examined whether the pattern of glycemic control, tolerability, and risk of
nocturnal hypoglycemia was achieved with continued use of Glar-300 for a further 6 mo interval of randomized but less intensively supervised treatment.
(2) The risk of hypoglycemia was statistically significantly decreased in the IDeg treatment group as compared to that in the IGlar treatment group of patients with T2DM, as was
nocturnal hypoglycemia. While in patients with T1DM, the IDeg treatment was associated with a lower risk of
nocturnal hypoglycemia, but not associated with a lower risk of overall hypoglycemia.
In contrast, patients with moderate-capacity, low-affinity IAs may suffer from moderate
nocturnal hypoglycemia. Patients with high-capacity, low-affinity IAs may suffer severe daytime hyperglycemia and nighttime hypoglycemia and may require treatment with immunosuppressants (5).
Nocturnal hypoglycemia occurs when blood glucose levels fall below the target physiological level (4 mmol/l or 72 mg/dl) at night time.
Hershey et al., "Impact of
nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes," Diabetes, vol.
A prospective metaanalysis of phase Ma trials comparing insulin degludec with insulin glargine showed that type 1 diabetes patients who were on degludec had a statistically significant 17% lower rate of
nocturnal hypoglycemia across the entire treatment period and a 25% lower rate over the maintenance period (16 weeks onward), compared with those on glargine (Diabetes Obes.
In fact,
nocturnal hypoglycemia is the main barrier to reaching glycemic targets," she noted.
While improvements in HbA1c were comparable, the group who switched to insulin glargine showed a 25% decrease in the rate of
nocturnal hypoglycemia (26.5% versus 35.5%, p = 0.0136).
However this type of activity may increase the risk of
nocturnal hypoglycemia afterwards.
He worried less about
nocturnal hypoglycemia when he started dialysis over five years ago because he was married to a nurse.
It can be used to identify
nocturnal hypoglycemia or hyperglycemia after meals, allowing for therapy adjustments to improve glucose control thus lowering the risk of diabetes complications such as blindness, kidney failure, impotence, amputation and heart disease.
Nocturnal hypoglycemia was defined as symptoms of hypoglycemia occurring after the last insulin injection and before the morning insulin dose.
