After the results of the 24-h insulin profile were explained to the patient, there were no further occurrences of nocturnal hypoglycemia
Less nocturnal hypoglycemia
and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes.
The phenomenon of nocturnal hypoglycemia
results primarily from a mismatch between nighttime insulin requirements and the peak action of older intermediate or long-acting insulin preparations (eg, NPH, lente or ultralente, respectively).
The second study objective is to demonstrate that home use of LGS is associated with a reduction in nocturnal hypoglycemia
when patients fail to respond.
What we've seen from the Phase III trials are unprecedented results in the basal insulin space: superior glycemic control with less nocturnal hypoglycemia
and reduced weight gain, all of which are important to physicians and patients.
Detecting nocturnal hypoglycemia
can be challenging because during sleep patients will be unaware of symptoms if not awakened, and thus unable to self-treat.
BIL reduced the risk of nocturnal hypoglycemia
in type 1 trials:[sup.
The reduction of risk of hypoglycemia with degludec was particularly significant for nocturnal hypoglycemia
, the "important area of concern," Dr.
As a result of the natural progression of type 2 diabetes and loss of [beta]-cell function, traditional treatment regimens incorporating oral agents often fail to help patients achieve these goals over the long term, exposing them to nocturnal hypoglycemia
and fasting and postprandial hyperglycemia.
Inside Insulin: 5 Sets of Facts, Figures, and Findings : This concise slide show summarizes new research on the use of premixed biphasic insulin and the impact on nocturnal hypoglycemia
of investigational U300 insulin glargine.
The Effect of Insulin Degludec on Glycemic Control and Nocturnal Hypoglycemia
Compared with Insulin Glargine: A 1-year Randomized Trial in Insulin-naive People with Type 2 Diabetes.
Surprisingly, more than half (58%) of the 102 hypoglycemic episodes occurred in the 16 patients with type 2 diabetes, with a mean duration of nocturnal hypoglycemia
nearly twice that of the hypoglycemia in the type 1 patients (2.