nociceptors


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Related to nociceptors: Pacinian corpuscle, Gate control theory

nociceptors

Nerve endings selectively responding to painful stimuli. Stimulation of nociceptors causes the sensation of pain.
References in periodicals archive ?
PGs synthesized by COX-2 increase the sensitivity of nociceptors to the chemical mediators, thus increasing pain.
Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains.
This increase in perceived pain could be related to an increased sensitivity of nociceptors, similar to the effects of the PPT algometer (Aboodarda et al., 2015; Cavanaugh et al., 2017).
TRP channels are involved with the pain-sensing neurons and primer afferent nociceptors. NSAIDs have effects, such as inhibition, activation, or expression, on channels, which may be voltage-gated Na+, [Ca.sup.2+], or [K.sup.+] channels; ligand-gated [K.sup.+] channels; or TRP cation channels (7, 40).
Receptors, especially nociceptors, send pain signals to the brain.
Psychophysical evidence of nociceptor sensitization in vulvar vestibulitis syndrome.
There are three pharmacologic strategies for the management of post-endodontic pain: 1) Drugs that block inflammatory mediators that activate or sensitize pulpal nociceptors (e.g., NSAIDs and glucocorticoids); 2) Drugs that block impulse propagation along the peripheral nerves; and 3) Drugs that block central mechanisms of hyperalgesia and pain perception.4 Glucocorticoids suppress the inflammatory mediators.
Spasticity can be caused by pain: sensory disturbances, excessive stress on joint and muscles when they are stretched, disruption of some muscle fibers occur and release substances which influence nociceptors. Vs.
[1], the transmission of pain impulses may be suppressed via activation of mAChRs that are located on peripheral nociceptors of the skin.
Hou et al., "Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects," PLoS One, vol.