nobiletin

nobiletin

A bitter citrus flavonoid found in tangerines, which is structurally similar to tangeretin.

Possible benefits
Antiatherogenic (inhibits deposition of lipid-laden macrophages in arterial walls, and reduces VLDL-triglyceride secretion), anti-inflammatory (acts as an antioxidant), anti-neoplastic (reduces proliferative activity in liver, stomach, prostate and colon cell lines) and allegedly improves memory and fights acne.
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References in periodicals archive ?
Nobiletin strongly promotes differentiation of 3T3-L1 preadipocytes to mature adipocytes through the transcriptional activation of peroxisome proliferator-activated receptor [gamma] (PPAR-[gamma]), yet lacks ligand-binding activity (Horikawa et al.
Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.
A control group received the same diet but with nobiletin added.
Nobiletin is a flavonoid that is commonly found in tangerines.
In spite of the antibacterial effects of quercetin in herbs (tea, elderflowers, spices), nobiletin in the white lining of citrus peels (lemon, orange) is twice as potent against bacterial infections.
We recently found a citrus polymethoxy flavonoid, nobiletin (5,6,7,8,3',4'-hexamethoxyflavone), that exhibits multiple pharmacological actions in both in vivo and in vitro models of rheumatoid arthritis, tumorigenesis, tumour invasion and metastasis, and photoageing [14-21].
The early studies involving orange juice have identified that heptamethoxyflavone (HMF), tangeretin, and nobiletin are not only substrates for both P-glycoprotein and OATP, but also are inhibitors that decrease the bioavailability significantly of other substrates, such as fexofenadine.
Rikako Suzuki of Kanazawa Medical University in Japan found that nobiletin, a chemopreventative compound found in oranges and other citrus fruit, also helped prevent colon cancer in animal studies.
Punches (3 mm) were obtained from the posterior sclera of chick eyes and immediately placed in multiwell plates containing Dulbecco's Modified Eagle's Medium (DMEM) alone (controls) or DMEM containing Tissue Inhibitor of Metalloproteinase CRIMP)--2, a natural inhibitor of gelatinase A, Nobiletin, a citrus flavonoid, or Captopril, an inhibitor of angiotensin converting enzyme, which also blocks activity of [Zn.
Individually, the best performers against both types of cells were tangeretin and nobiletin, a pair of flavonoids from tangerines.
We use HGF as an invasive inducer of human HepG2 cells to investigate the effect of four flavones including apigenin, tricetin, tangeretin, and nobiletin on HGF/c-Met-mediated tumor invasion and metastasis.
Suppressive effects of citrus fruits on free radical generation and nobiletin, an antiinflammatory polymethoxyflavonoid.