nobiletin

nobiletin

A bitter citrus flavonoid found in tangerines, which is structurally similar to tangeretin.

Possible benefits
Antiatherogenic (inhibits deposition of lipid-laden macrophages in arterial walls, and reduces VLDL-triglyceride secretion), anti-inflammatory (acts as an antioxidant), anti-neoplastic (reduces proliferative activity in liver, stomach, prostate and colon cell lines) and allegedly improves memory and fights acne.
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References in periodicals archive ?
The TCMF consists of calycosin, liquiritin, eucommiol, 6-gingerol, ursolic acid, atractyloside, glycyrrhizic acid, chlorogenic acid, salidroside, nobiletin, and specnuezhenide effective ingredients.
40) reported that flavonoids tangeretin and nobiletin effectively inhibited NF-[kappa]B activation and histamine action following histamine-stimulation in mice.
The findings suggested that the citric acid contains a chemical nobiletin, which in animal tests has shown to slow or reverse impairment of memory.
Using enzyme-linked immunosorbent assay (ELISA) the researchers showed that the quantity of guanidine-soluble A[beta]-40 and A[beta]-42 was greatly reduced in the brain following nobiletin administration to transgenic mice for 4 months (Onozuka, et al.
For example, nobiletin inhibits PDGF-BB and Ang-II stimulated proliferation and migration of VSMCs, as well as reduces ROS production, ERK1/2 phosphorylation and NF-[kappa]B expression (Guan et al.
2011), flavonoids such as hesperidin, ferulic acid, tangeretin, sinensetin, nobiletin (Malterud and Rydland 2000; Luo et al.
Nobiletin (Figure 1(j)), a flavonoid purified from Citrus depressa plant, prevents memory loss in APP695 transgenic mice and A[beta] treated rats.
The major chemical constituents reported in Citrus fruits are flavonoids including hesperitin, hesperidin, neohesperidin, naringenin, tangeritin, auranetin, quercetin, nobiletin [32], limonene, myrcene [33], AY- sitosterol [34] and adrenergic amines including synephrine, octopamine and tyramine [35].
Plus, orange peels are rich in tangeretin and nobiletin - flavonoids that boast anticancer, antidiabetic and anti-inflammatory properties.
Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.
Suppressive effects of citrus fruits on free radical generation and nobiletin, an antiinflammatory polymethoxyflavonoid.
A control group received the same diet but with nobiletin added.