nizatidine


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Related to nizatidine: omeprazole

nizatidine

 [nĭ-za´tĭ-dēn]
a histamine H2 receptor antagonist, used to inhibit gastric acid secretion in the treatment of gastric and duodenal ulcer, gastroesophageal reflux disease, and conditions that cause gastric hypersecretion; administered orally.

nizatidine

Apo-Nizatidine, Axid, Axid AR, Dom-Nizatidine, Gen-Nizatidine, Novo-Nizatidine, PHL-Nizatidine, PMS-Nizatidine, Zinga (UK)

Pharmacologic class: Histamine2 (H2)-receptor antagonist

Therapeutic class: Antiulcer drug

Pregnancy risk category B

Action

Inhibits histamine action at H2-receptor sites in gastric parietal cells, reducing gastric acid secretion and pepsin production

Availability

Capsules: 150 mg, 300 mg

Oral solution: 15 mg/ml

Tablets: 75 mg

Indications and dosages

Active duodenal ulcer Adults: 300 mg P.O. daily at bedtime or 150 mg b.i.d. for up to 8 weeks

Maintenance of healed duodenal ulcers

Adults and children ages 12 and older: 150 mg P.O. daily at bedtime for up to 1 year

Esophagitis and associated heartburn caused by gastroesophageal reflux disease (GERD)

Adults: 150 mg P.O. b.i.d. for up to 12 weeks

Active benign gastric ulcer Adults: 150 mg P.O. b.i.d. or 300 mg P.O. once daily at bedtime

Erosive esophagitis; GERD

Children ages 12 and older: 150 mg P.O. b.i.d. for up to 8 weeks

Dosage adjustment

• Moderate to severe renal impairment

• Elderly patients

Contraindications

• Hypersensitivity to drug or other H2-receptor antagonists

Precautions

Use cautiously in:

• mild renal impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 12 (safety and efficacy not established).

Administration

• Give with or without food.

• If patient is to take drug twice daily, give one dose in morning and one at bedtime.

Adverse reactions

CNS: dizziness, drowsiness, headache, anxiety, nervousness, insomnia, abnormal dreams, asthenia

CV: chest pain

EENT: amblyopia, sinusitis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain, flatulence, anorexia, dry mouth

Hematologic: anemia

Musculoskeletal: back pain, myalgia

Respiratory: cough

Skin: rash, pruritus

Other: tooth disorder, infection, fever, pain

Interactions

Drug-drug. Salicylates (high doses): increased salicylate blood level

Drug-diagnostic tests. Alanine amino-transferase, alkaline phosphatase, aspartate aminotransferase: elevated levels

Urobilinogen tests using Multistix: false-positive result

Drug-herbs. Pennyroyal: altered rate of herbal metabolite formation

Patient monitoring

• Monitor liver and renal function tests.

• Check temperature; watch for fever and other signs and symptoms of infection.

Patient teaching

• Advise patient to take once-daily dose at bedtime with or without food, or twice-daily doses in morning and at bedtime.

• Instruct patient to take exactly as prescribed. Caution him not to take other OTC drugs (especially aspirin).

• Tell patient to report signs and symptoms of infection.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

nizatidine

/ni·za·ti·dine/ (nĭ-zat´ĭ-dēn) a histamine H2 receptor antagonist, used to inhibit gastric acid secretion in the treatment of gastric and duodenal ulcer, gastroesophageal reflux disease, and conditions that cause gastric hypersecretion.

nizatidine

(nī-zăt′ĭ-dēn′)
n.
A histamine receptor antagonist, C12H21N5O2S2, that inhibits the secretion of gastric acid and is used to treat duodenal and gastric ulcers and gastroesophageal reflux disease.

nizatidine

A H2-receptor antagonist used to treat peptic ulcer disease.
 
Adverse reactions
Diarrhoea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynaecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis.

nizatidine

Axid® Therapeutics An H2-receptor antagonist used to treat peptic ulcer disease Adverse reactions Diarrhea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis, etc. See Histamine receptor antagonists.

nizatidine

An H2 RECEPTOR ANTAGONIST drug used to prevent and treat peptic ulcers. Brand names are Axid and Zinga.

nizatidine

a histamine H2-receptor antagonist, similar to cimetidine, used to reduce gastric acidity in the treatment of gastrointestinal ulceration.
References in periodicals archive ?
Nizatidine ameliorates gastroparesis in Parkinson's disease: A pilot study.
As with famotidine, the Drug Facts Label for OTC ranitidine, cimetidine, and nizatidine do not contain recommendations for dose reductions based upon age or kidney dysfunction.
2003, Nizatidine treatment and its relationship with leptin levels in patients with olanzapineinduced weight gain, Human Psychopharmacology : Clinical and Experimental, 18, 6, 457-461.
In addition, five reviews on the treatment of GERD in pregnancy have concluded that these agents, with the possible exception of nizatidine, arc relatively sate (Drug Sal.
5 mg/d for short-term management of obesity, oxcarbazepine, 600 mg/d for supposed partial seizures, sertraline, 100 mg/d for depression, aripiprazole, 10 mg/d, and nizatidine, 150 mg/d, for gastroesophageal reflux disease.
Standard heartburn medications that are not PPIs, including famotidine (Pepcid[R]), nizatidine (Axid[R]), and ranitidine (Zantac[R]), do not seem to be related to heart problems in this report.
In addition to famotidine, H2 blockers include cimetidine (Tagamet), ranitidine (Zantac) and nizatidine (Axid).
3 December 2009 - US-based generic pharmaceuticals maker Amneal Pharmaceuticals LLC said today it has obtained US Food and Drug Administration (FDA) approval to manufacture Nizatidine Oral Solution in the 15 mg/mL strength effective 18 November 2009.
2] blockers ranitidine (Zantac), famotidine (Pepcid), and nizatidine (Axid.
The agency is recommending the use of the H2 blockers ranitidine (Zantac), famotidine (Pepcid), and nizatidine (Axid) for reducing stomach acid in patients on clopidogrel.
The following drugs deplete vitamin D: barbiturates, carbamazepine, cholestyramine, cimetidine, colestipol, corticosteroids, famotidine, fosphenytoin, isoniazid, mineral oil, nizatidine, phenobarbital, phenytoin, ranitidine, and rifampin.