nitrosourea


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nitrosourea

 [ni-tro″so-u-re´ah]
any of a group of cell cycle phase nonspecific, lipid soluble biological alkylating agents, including carmustine, lomustine, semustine, and streptozocin; they cross the blood-brain barrier and are used as antineoplastic agents. Streptozocin is an antibiotic that contains a nitrosourea group and differs somewhat in action from the other three.

ni·tro·so·ur·e·a

(nī-trō'sō-ūr'ē-ă),
Alkylating agent used in the treatment of many neoplasms; an example is BCNU.

nitrosourea

/ni·tro·so·urea/ (ni-tro″so-u´re-ah) any of a group of lipid-soluble biological alkylating agents, including carmustine and lomustine, which cross the blood-brain barrier and are used as antineoplastic agents.

nitrosourea

[nītrō′sōyoo͡rē′ə]
one of a group of alkylating drugs used as antineoplastic drugs in the chemotherapy of brain tumors, multiple myeloma, Hodgkin's disease, adenocarcinomas, hepatomas, chronic leukemias, lymphomas, myelomas, and cancers of the breast and ovaries. They have been less successful in therapy for cancers of the lungs, head, neck, and GI tract. Like other alkylating agents, they have severe toxic effects, including bone marrow depression. Nausea and vomiting are almost always present. These drugs can cause fetal harm and should not be used during pregnancy. Carmustine and lomustine are typical examples of this group. See also alkylating agent.

nitrosourea

Oncology Any of a group of lipid-soluble alkylating anticancer drugs–carmustine–BCNU, lomustine–CCNU, which cross the blood-brain barrier, and are used to manage brain tumors

nitrosourea

any of a group of lipid-soluble biological alkylating agents, including carmustine and lomustine, which cross the blood-brain barrier and are used as antineoplastic agents.
References in periodicals archive ?
Other second-line options for patients with good performance status include high-dose interleukin-2 (not suitable for patients with inadequate organ reserve, poor performance status, or untreated or active brain metastases), biochemotherapy and cytotoxic agents (dacarbazine or temozolomide, and cisplatin or carboplatin, with or without vinblastine or nitrosourea, and IL-2 and interferon alfa-2b; paclitaxel, albumin-bound paclitaxel).
Mechanism of comutagenesis of sodium arsenite with N- methyl-N- nitrosourea.
Further, for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly, Temozolomide Capsules are noted along the radiotherapy and also as maintenance treatment and for adult patients with refractory anaplastic astrocytoma who have intimate disease progression on a drug regimen containing nitrosourea and precarbazine.
Each wafer contains the nitrosourea alkylating agent carmustine distributed in a biodegradable polymer matrix.
The product is intended to treat adult patients that have been recently diagnosed with glioblastoma multiforme, concomitantly with radiotherapy and then as maintenance treatment and also refractory anaplastic astrocytoma patients whose disease has progressed on a drug regimen containing nitrosourea and procarbazine.
DNA cross-linking and monoadduct repair in nitrosourea treated human tumor cells.
Combination of radiotherapy with alkylating agents such as bischloroethyl nitrosourea (BCNU) has shown a definite, though small increase in the survival of patients with anaplastic astrocytoma.
Because the combination of a nitrosourea and spinal cord irradiation made this patient more susceptible to bone marrow suppression, physicans planned to perform a complete blood count every 2 weeks.
In 1999 Temodar was granted accelerated approval for the treatment of adult patients with anaplastic astrocytoma (another form of brain cancer) in relapse after chemotherapy with nitrosourea and procarbazine.
He and a team of researchers have developed a way to measure the ability of particular cancer cells to repair the damage done to DNA by a category of commonly utilized anti-cancer drugs that are known as alkylating agents, including nitrosourea and cisplatinin.