To assess the role of STAT3 in gastric carcinogenesis, we induced gastric cancer in [Stat3.sup.[DELTA]gec] mice using the chemical carcinogen Nmethyl-N-
nitrosourea (MNU) [33, 37, 38].
At eleven weeks after the surgeries, all rats were injected with streptozotocin (STZ), which is a
nitrosourea analog and selectively induces pancreatic beta cell death by alkylation of DNA (Delaney et al.
Environmental triggers include viruses (Coxsackie, rubella, enterovirus), bovine milk proteins and
nitrosourea. [1]
Other second-line options for patients with good performance status include high-dose interleukin-2 (not suitable for patients with inadequate organ reserve, poor performance status, or untreated or active brain metastases), biochemotherapy and cytotoxic agents (dacarbazine or temozolomide, and cisplatin or carboplatin, with or without vinblastine or
nitrosourea, and IL-2 and interferon alfa-2b; paclitaxel, albumin-bound paclitaxel).
Mechanism of comutagenesis of sodium arsenite with N- methyl-N-
nitrosourea. Biol.
(1) demonstrated that resistance acquired by tumor cells during treatment with alkylating agents (
nitrosourea and carmustine/BCNU) was maintained by intermittent treatment with low concentrations of chemotherapy agents.
Further, for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly, Temozolomide Capsules are noted along the radiotherapy and also as maintenance treatment and for adult patients with refractory anaplastic astrocytoma who have intimate disease progression on a drug regimen containing
nitrosourea and precarbazine.
Zanosar (common name streptozotocin) is a chemotherapy agent in the
nitrosourea class.
The reported cooperative effects of MJ with other drugs are shown in Table 3: (1) BCNU (carmustine), an alkylating
nitrosourea agent with no cytotoxic effect on pancreatic carcinoma cell line MIA PaCa-2 in vitro combined with MJ showed enhanced cell death [170].
Each wafer contains the
nitrosourea alkylating agent carmustine distributed in a biodegradable polymer matrix.
The product is intended to treat adult patients that have been recently diagnosed with glioblastoma multiforme, concomitantly with radiotherapy and then as maintenance treatment and also refractory anaplastic astrocytoma patients whose disease has progressed on a drug regimen containing
nitrosourea and procarbazine.
STZ is a
nitrosourea derivative isolated from streptomyces achromogenes.
