nitrogen mustard


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mustard

 [mus´terd]
1. a plant of the genus Brassica.
2. the ripe seeds of Brassica alba (white mustard) and B. nigra (black mustard), whose oils have irritant, stimulant, and emetic properties.
3. resembling, or something resembling, mustard in one or more of its properties.
nitrogen mustard mechlorethamine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

nitrogen mustard

n.
One of a group of toxic organic compounds that are structurally similar to mustard gas but contain nitrogen instead of sulfur, used primarily as chemotherapeutic agents.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

MOPP

A 4-drug chemotherapy regimen for stage-III Hodgkin lymphoma.
 
Adverse effects
Sterility, nausea, vomiting, immunosuppression, increased infections, myelosuppression, myelodysplasia, ANLL.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

nitrogen mustard

Oncology Any of a family of alkylating agents used primarily to treat NHLs,  Hodgkin's disease, ALL, mycosis fungoides; NMs  enter cells via the choline transport system; tumor cells may develop mustard resistance through enhanced repair of alkylated DNA or thiol-mediated mustard inactivation Toxicity GI tract–N&V, myelosuppression with pancytopenia, alopecia, tissue injury, diarrhea, diaphoresis
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

nitrogen mustard

A drug used in the treatment of cancer. Nitrogen mustard is an ALKYLATING AGENT.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
"Nitrogen mustard was the first use of systemic therapy based on the premise that treatment failure was due to circulating cancer cells.
A group of 10 patients applied nitrogen mustard unilaterally daily, then dropped back to three times per week as their hair grew in.
KEY WORDS: cerebellum, DNA damage, granule cell, HN2, MAM, methylazoxymethanol, nitrogen mustard. Environ Health Perspect 114:1703-1712 (2006).
Methylazoxymethanol (MAM) and nitrogen mustard (HN2) are two established genotoxicants that reproducibly disrupt neuronal development when administered during the fetal or neonatal period of CNS development (Cattabeni and Di Luca 1997; Ferguson 1996; Graef et al.
In vitro neurotoxic and DNA-damage properties of nitrogen mustard (HN2).
Alkylation of DNA by the nitrogen mustard bis(2-chloroethyl) methylamine.
At the Mayo Clinic, the practice is to treat patients conservatively, using topical nitrogen mustard and phototherapy with UVB or PUVA.
During the Second World War scientists at the establishment, set in 6,000 acres of countryside in Salisbury, Wilts, carried out research on chemical weapons such as nitrogen mustards and biological agents including anthrax.
This group of chemical warfare agents includes sulfur mustard, Lewisite [dichloro(2-chlorovinyl)arsine], and nitrogen mustards. Nitrogen mustards have not been produced in substantial quantities, and they have some medicinal use as anticonvulsant agents (29).