nitrogen mustard


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mustard

 [mus´terd]
1. a plant of the genus Brassica.
2. the ripe seeds of Brassica alba (white mustard) and B. nigra (black mustard), whose oils have irritant, stimulant, and emetic properties.
3. resembling, or something resembling, mustard in one or more of its properties.
nitrogen mustard mechlorethamine.

nitrogen mustard

n.
One of a group of toxic organic compounds that are structurally similar to mustard gas but contain nitrogen instead of sulfur, used primarily as chemotherapeutic agents.

nitrogen mustard

MOPP

A 4-drug chemotherapy regimen for stage-III Hodgkin lymphoma.
 
Adverse effects
Sterility, nausea, vomiting, immunosuppression, increased infections, myelosuppression, myelodysplasia, ANLL.

nitrogen mustard

Oncology Any of a family of alkylating agents used primarily to treat NHLs,  Hodgkin's disease, ALL, mycosis fungoides; NMs  enter cells via the choline transport system; tumor cells may develop mustard resistance through enhanced repair of alkylated DNA or thiol-mediated mustard inactivation Toxicity GI tract–N&V, myelosuppression with pancytopenia, alopecia, tissue injury, diarrhea, diaphoresis

nitrogen mustard

A drug used in the treatment of cancer. Nitrogen mustard is an ALKYLATING AGENT.
References in periodicals archive ?
Methylazoxymethanol (MAM) and nitrogen mustard (HN2) are two established genotoxicants that reproducibly disrupt neuronal development when administered during the fetal or neonatal period of CNS development (Cattabeni and Di Luca 1997; Ferguson 1996; Graef et al.
In vitro neurotoxic and DNA-damage properties of nitrogen mustard (HN2).
Alkylation of DNA by the nitrogen mustard bis(2-chloroethyl) methylamine.
The in vivo genetic activity profile of the monofunctional nitrogen mustard 2-chloroethylamine differs drastically from its bifunctional counterpart mechlorethamine.
DNA damage and mutagenesis induced by nitrogen mustards.
The Chinese anti-tumor drugs can be divided into nine categories: Alkylation Agents, such as nitrogen mustards, ethylene-imines, methanesulfonates, polyatomic alcohols and SarCNU; Anti-metabolite drugs, such as pyrimidine antimetabolites, purine antimetabolites and antifolates; Antibiotics; Plant anti-tumor drugs; Hormone anti-tumor drugs; Platinum metallic anti-tumor drugs; Others; Aided anti-tumor Drugs and immunomodulators.