nitric oxide synthase


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Related to nitric oxide synthase: Neuronal Nitric Oxide Synthase

ni·tric ox·ide syn·thase (NO syn·thase, NOS),

an enzyme that catalyzes the reaction of l-arginine with 2O2 and 1.5NADPH to form NO, l-citrulline, 1.5NADP+, and 2H2O; there are an inducible and two constitutive forms of this enzyme: the constitutive forms play significant roles in regulating vascular tone, tissue blood flow, renal function, and others; in bone, brain, endothelium, granulocytes, pancreatic Z-cells, and peripheral nerves, the constitutive forms depend on calcium-calmodulin; in brain, the enzyme is cytosolic; in endothelium, it is membrane bound; the inducible form of the enzyme (for example, by endotoxin) in hepatocytes, Kupffer cells, macrophages, and smooth muscle is not calmodulin dependent.

nitric oxide synthase

Abbreviation: NOS
An enzyme that synthesizes nitric oxide from arginine; present in the central nervous system, the lining of blood vessels, the heart, joints, some autonomic neurons, and other organs.
See also: synthase

nitric oxide synthase

One of three enzymes that catalyze the synthesis of NITRIC OXIDE in blood vessel ENDOTHELIUM, nerve fibres and MACROPHAGES. These enzymes are coded for, respectively, on chromosomes 7, 12 and 17. They act by splitting off a nitrogen atom from the amino acid L-arginine which is then combined with an oxygen atom from molecular oxygen to form NO.
References in periodicals archive ?
It was shown that chronic hypoxia decreases eNOS and increases nNOS in brain tissue.17 In addition, elevated synthesis of glutamate and extracellular amino-terminal fragment (ATF), and processes of long-term and severe hypoxia cause changes in enzyme activity related to 2, 4-Dinitrotoluene (DNT) structure, resulting in activation of neuronal and inducible forms of nitric oxide synthases.18,19
Nitric oxide synthase activity and expression are decreased in the paraventricular nucleus of pregnant rats.
Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.
Caption: Figure 2: (a) Histology of healing wound tissue by hematoxylin and eosin stain at the indicated time intervals in dorsal skin of inducible nitric oxide synthase (iNOS-) knockout (KO) mice and WT mice.
Ye, "Endothelial nitric oxide synthase dimerization is regulated by heat shock protein 90 rather than by phosphorylation," PLoS One, vol.
Kamogawa et al., "Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters," Circulation Journal, vol.
Souza et al., "Nitric oxide synthase (NOS) characterization in Leishmania amazonensis axenic amastigotes," Archives of Medical Research, vol.
Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation.
Endothelial nitric oxide synthase gene G894T polymorphism and myocardial infarction: a meta-analysis of 34 studies involving 21068 subjects.
Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes.
Key words: Arginine, Broiler, Cytokine, Nitric Oxide Synthase, mRNA Expression.
It has been observed that NO synthesis is increased in endometrial tissue from women with endometriosis (7), and changes have been observed in endothelial nitric oxide synthase (eNOS) expression in the endometrium of women with endometriosis (27,28) that can be associated with specific gene polymorphisms of eNOS (29).

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