nitidine

nitidine

Pharmacognosy
A chemical found in prickly ash (Zanthoxylum americana), which has been shown to have anticarcinogenic activity in animals as well as antimalarial activity.
References in periodicals archive ?
Jiang, "DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine," Bioorganic and Medicinal Chemistry, vol.
In previous studies, we revealed the specific accumulation of nitidine (NTD) in intracellular particles as suggestive of certain organelles [6, 7].
Lin et al., "Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer," Molecular Cancer Therapeutics, vol.
Wang et al., "Nitidine chloride induces apoptosis, cell cycle arrest, and synergistic cytotoxicity with doxorubicin in breast cancer cells," Tumor Biology, vol.
Manikumar, "Human DNA topoisomerase I: quantitative analysis of the effects of camptothecin analogs and the benzophenanthridine alkaloids nitidine and 6-ethoxydihydronitidine on DNA topoisomerase I-induced DNA strand breakage," Archives of Biochemistry and Biophysics, vol.
Smith, "Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride," Journal of Medicinal Chemistry, vol.
bungeanum leaves; (2) to measure the antioxidant and antimicrobial activities of the different polarity fractions; (3) to quantify the content of twelve natural compounds (chlorogenic acid, epicatechin, rutin, hyperoside, trifolin, quercitrin, kaempferol-3-rhamnoside, quercetin, nitidine chloride, chelerythrine, xanthyletin, and sesamin) in the different polarity fractions by RP-HPLC analysis; and (4) to compare the similarities and differences of the phytochemical composition in the different polarity fractions.
Louis, uSa); vanillin, bromocresol green, tetrahydrofuran (THF), sodium borohydride, and trifluoroacetic acid (Chengdu Kelong Chemical Co., Ltd., China); chloranil (Aladdin Industrial Corporation, Shanghai, China); gallic acid, chlorogenic acid, epicatechin, rutin, hyperoside, trifolin, quercitrin, kaempferol-3-rhamnoside, quercetin, nitidine chloride, chelerythrine, xanthyletin, and sesamin (Shanghai Winherb Medical Science Co., Ltd.); and amphotericin and benzylpenicillin (Shanghai Sunny Biotechnology Co.
The content of twelve compounds (chlorogenic acid, epicatechin, rutin, hyperoside, trifolin, quercitrin, kaempferol-3-rhamnoside, quercetin, nitidine chloride, chelerythrine, xanthyletin, and sesamin) was assayed using an Agilent Technologies 1260 series liquid chromatograph (RP-HPLC) coupled with a variable wavelength detector.
Epicatechin (27.45 mg/g), rutin (16.86 mg/g), hyperoside (19.25 mg/g), quercitrin (16.73 mg/g), chlorogenic acid (3.78 mg/g), kaempferol-3-rhamnoside (3.75 mg/g), trifolin (4.53 mg/g), and sesamin (5.13 mg/g) were the major phenolic components in ECE, other compounds (quercetin, nitidine chloride, chelerythrine, and xanthyletin) had a lower level of content (less than 1 mg/g).
Among the five subfractions, peaks 1-9 (chlorogenic acid, epicatechin, rutin, hyperoside, trifolin, quercitrin, kaempferol-3-rhamnoside, quercetin, and nitidine chloride) were common peaks in EAF and AF.