Hyaluronic acid, laminin, fibronectin, merosin, tenascin, and nidogen
are the main glycoproteins involved in liver functions (3).
Vertebrate laminin, nidogen
, and heparan sulfate were present in many molluscan basement membranes.
Shah, "Meprin A, the major matrix degrading enzyme in renal tubules, produces a novel nidogen
fragment in vitro and in vivo" Kidney International, vol.
In the first attempts to create a feeder-free culture system, Matrigel which is a protein mixture derived from mouse sarcoma cells, containing laminin (LN) 111, type IV collagen, perlecan, and nidogen
, as well as several unknown components and growth factors, was used .
It is made mostly of collagen type IV and glycoproteins, such as laminin and nidogen
. Degradation of ECM components occurs with the contribution of extracellular matrix metalloproteinases (MMPs).
The basement membrane, however, may also play a beneficial role, as wound healing is impaired in mice lacking the basement membrane component nidogen
It was demonstrated that neural progenitors (NPs) derived from hEnSCs can express correlative markers such as Pax6, Nidogen
, and Sox1 and it might experience pluripotency differentiation to neuroglial and neurons.
Among them, laminin consisting of a, P, and y chains as a heterotrimer (Ooba et al., 2008) play an important role in constructing STBM by constituting networks independently (Ooba et al., 2008) or with collagen IV via nidogen
and perlecan (Ooba et al., 2008).
It is a member of matrix metalloproteinase (MMP) family in the ECM which breaks substrates such as aggrecan, versican, brevican, nidogen
, and procollagen.
Nischt, "Skin basement membrane: the foundation of epidermal integrity-BM functions and diverse roles of bridging molecules nidogen
and perlecan," BioMed Research International, vol.
NID2 is homologous to another member of the nidogen
family, NID1, and both are found in all basement membranes (BMs) .
ECM consists of type IV collagen, laminin, heparan sulfate proteoglycan, nidogen
, and fibronectin (Nakajima et al.