It is made mostly of collagen type IV and glycoproteins, such as laminin and nidogen
2008) or with collagen IV via nidogen
and perlecan (Ooba et al.
It is a member of matrix metalloproteinase (MMP) family in the ECM which breaks substrates such as aggrecan, versican, brevican, nidogen
, and procollagen.
ECM consists of type IV collagen, laminin, heparan sulfate proteoglycan, nidogen
, and fibronectin (Nakajima et al.
34 Abbreviations: BBX, bobby sox homolog (Drosophila); WDPCP, WD repeat containing planar cell polarity effector; PITRM1, pitrilysin metallopeptidase 1; RPL6P18, ribosomal protein L6 pseudogene 18; SNEDI, sushi, nidogen
and EGF-like domains 1; SORCS, sortilin- related VPStQ domain containing receptor3; TAf2Gf.
Takagi J, Yang Y, Liu JH, Wang JH, Springer TA: Complex between nidogen
and laminin fragments reveals a paradigmatic beta-propeller interface.
Uptake and degradation in vivo and in vitro of laminin and nidogen
by rat liver cells.
The highest similarity score of the sponge nidogen was found to be with the related mucin sequences, the predicted mucin-4-like polypeptide from Amphimedon queenslandica (XP_003389333.
Mucin-Related Sponge Nidogen Polypeptide Induces Biosilica Gel Formation
For cell--cell interaction genes and genes involved in signal transduction, marked increases occurred in annexin A2 (48-fold), nidogen
1 (50-fold), E-cadherin (11-fold), and [beta]-catenin (7-fold) in arsenic-induced HCC.