In order to verify the subtype of neuronal nicotinic receptor
that the peptide acts, PC12 cells were employed and maintained in culture according to Greene et al.
Using genetic strategies, they are attempting to determine the specific molecular make-up of the nicotinic receptors
that regulate anxiety.
The actions of acetylcholine in the periphery are the result of activation of either inotropic nicotinic receptor
or the metabotropic muscarinic receptor (Caufield and Birdsall, 1998).
It seemed that nicotinic receptors
' pedigree presented a public relations headache.
Mecamylamine is a broad-spectrum nicotinic receptor
antagonist, meaning that it blocks receptors located in the periphery of,, as well as those in, the CNS.
Deletion of the alpha7 nicotinic receptor
subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.
Targacept is a biopharmaceutical company engaged in the design, discovery and development of a new class of drugs to treat multiple diseases and disorders of the central nervous system by selectively targeting neuronal nicotinic receptors
, or NNRs.
PREPARATION AND LABELING OF HUMAN NICOTINIC RECEPTORS
Consolidating evidence for a role of nicotinic receptors
also emerges from studies in which IT or speed of information processing measures have been assessed in patients with nicotinic Ach receptor (nAchRs) loss.
However, unlike other therapies, research indicates that Reminyl has a second mechanism of action: it acts on nicotinic receptors
in the brain.
"Reports suggest that stimulation of nicotinic receptors
may be associated with fewer of the amyloid plaques that are a hallmark of Alzheimer's."
Nicotinic symptoms develops 12-96 hours after exposure and reflects a prolonged action of acetylcholine on the nicotinic receptors
and is characterised by muscular weakness in the ocular, neck, bulbar, proximal limb, and respiratory muscles.