In order to verify the subtype of neuronal
nicotinic receptor that the peptide acts, PC12 cells were employed and maintained in culture according to Greene et al.
Using genetic strategies, they are attempting to determine the specific molecular make-up of the
nicotinic receptors that regulate anxiety.
The actions of acetylcholine in the periphery are the result of activation of either inotropic
nicotinic receptor or the metabotropic muscarinic receptor (Caufield and Birdsall, 1998).
It seemed that
nicotinic receptors' pedigree presented a public relations headache.
Mecamylamine is a broad-spectrum
nicotinic receptor antagonist, meaning that it blocks receptors located in the periphery of,, as well as those in, the CNS.
Deletion of the alpha7
nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.
Targacept is a biopharmaceutical company engaged in the design, discovery and development of a new class of drugs to treat multiple diseases and disorders of the central nervous system by selectively targeting neuronal
nicotinic receptors, or NNRs.
PREPARATION AND LABELING OF HUMAN
NICOTINIC RECEPTORSConsolidating evidence for a role of
nicotinic receptors also emerges from studies in which IT or speed of information processing measures have been assessed in patients with nicotinic Ach receptor (nAchRs) loss.
However, unlike other therapies, research indicates that Reminyl has a second mechanism of action: it acts on
nicotinic receptors in the brain.
"Reports suggest that stimulation of
nicotinic receptors may be associated with fewer of the amyloid plaques that are a hallmark of Alzheimer's."
Nicotinic symptoms develops 12-96 hours after exposure and reflects a prolonged action of acetylcholine on the
nicotinic receptors and is characterised by muscular weakness in the ocular, neck, bulbar, proximal limb, and respiratory muscles.