nicotinic receptors


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nic·o·tin·ic re·cep·tors

a class of cholinergic receptors on skeletal muscle cells that are linked to ion channels in the cell membrane.

nicotinic receptors

ACETYL CHOLINE receptors that also respond to NICOTINE. These receptors are at nerve-muscle junctions and in the autonomic nervous system.

nicotinic

pertaining to the transmission of nerve impulses mediated by nicotinic receptors.

nicotinic acid
see niacin.
nicotinic receptors
cholinergic receptors of autonomic ganglion cells and motor end-plates of skeletal muscle that are stimulated by low doses of nicotine and blockaded by high doses or by tubocurarine.
nicotinic synapses
synapses in which nicotinic transmitters effect the transmission of impulses.
References in periodicals archive ?
Alpha-7 nicotinic receptors in the cerebrum do not receive their cholinergic innervation until just before birth, when the cholinergic afferents from the midbrain reach the hippocampus, thalamus, and cerebral cortex.
Using genetic strategies, they are attempting to determine the specific molecular make-up of the nicotinic receptors that regulate anxiety.
However, unlike the lonely years of the 1990s, it's now difficult to find a major drug company not trying to capitalize on nicotinic receptors,
5-10 mg/day--one-tenth of the dosages used in hypertension the drug antagonizes CNS neuronal nicotinic receptors with no effect on those in the periphery--and no impact on blood pressure.
Long-term ethanol treatment elicits changes in nicotinic receptor binding in only a few brain regions.
Targacept is a biopharmaceutical company engaged in the design, discovery and development of a new class of drugs to treat multiple diseases and disorders of the central nervous system by selectively targeting neuronal nicotinic receptors, or NNRs.
This suggests that the biological interaction between the nicotinic receptors and AD pathology is complex," he said.
That is, nicotine is a cognitive-enhancing drug, with its administration activating presynaptic nicotinic receptors.
Reminyl also modulates nicotinic receptors in the brain so that they respond better to acetylcholine; this might be involved in the drug's beneficial effects, since nicotinic receptors are decreased in Alzheimer's disease, Dr.
However, unlike other therapies, research indicates that Reminyl has a second mechanism of action: it acts on nicotinic receptors in the brain.
Neuronal nicotinic receptors (NNRs) belong to the Cys-loop family of ligand-gated ion channels, are formed from five subunits either as homologous or heterologous, oligomeric receptors, and are of interest as targets for treatment of a variety of central and peripheral nervous system disorders.