nicorandil


Also found in: Wikipedia.

nicorandil

A POTASSIUM CHANNEL ACTIVATOR drug used to treat ANGINA PECTORIS. A brand name is Ikorel.
References in periodicals archive ?
Nicorandil, (a nitrate and K-channel activator) (104) and pioglitazone (a peroxisome proliferator-activated receptor [gamma] agonist) (105, 106) are also effective in suppressing CAS.
Organic nitrates, such as GTN, pentaerythritol tetranitrate, isosorbide dinitrate, isosorbide 5-mononitrate, and nicorandil, are transformed into NO by bioactivation.
Nicorandil protects the heart from ischemia/reperfusion injury by attenuating endoplasmic reticulum response-induced apoptosis through PI3K/Akt signaling pathway.
When the frequency was fixed at 1 Hz, lidocaine, nifedipine, diltiazem, nicorandil ([I.sub.KATP] activator), Ni[Cl.sub.2], and the hypotonic ([I.sub.Cl-vol] activator) and high [[[Na.sup.+]].sub.i] solution shortened APD50 and APD90.
Nicorandil (Tocris: Minneapolis, MN; TCI, Portland, OR) was administered in drinking water (15 mg/kg/day), based on an average of 5 mL of water consumed per day.
Melo et al., "Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice," European Journal of Pharmacology, vol.
Rizk, "Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats," Scientific Reports, vol.
Nicorandil, an association between a triphosphate-sensitive potasium channel opener and a nitrate, and Fasudil, an inhibitor of Rho-kinase, are useful for preventing anginal attacks.
Morimoto, "Species differences in percutaneous absorption of nicorandil," Journal of Pharmaceutical Sciences, vol.
In experimental MCT-induced PAH, the organic nitrate and [K.sup.+]-channel opener, nicorandil, showed beneficial effects: right ventricular systolic pressure (RVSP) was decreased, accompanied by higher expression of eNOS and less endothelial damage [22].
Yang et al., "Nicorandil protects the heart from ischemia/reperfusion injury by attenuating endoplasmic reticulum response-induced apoptosis through PI3K/Akt signaling pathway," Cellular Physiology and Biochemistry, vol.