Other compounds activated only the p53 pathway--including niclosamide
, rafoxanide, and chlorfenapyr--or the Nrf2/ARE pathway--including pinacyanol, 1,8-dihydroxy-4, 5-dinitroanthraquinone, 2-aminoanthraquinone, 2-hydrazino-4-(4-aminophenyl) thiazole, 2-hydrazino-4-(4-nitrophenyl)thiazole, and 2-hydrazino-4-phenylthiazole (Table 2).
Separate studies suggest that niclosamide
may be effective
"We will now take our findings to the next level by evaluating the ability of Niclosamide
to treat Parkinson's disease in disease models.
saginata, the number of illnesses may be underestimated because the decrease might also be explained by a shift of treatment from niclosamide
to praziquantel for this infection over the past decade in France.
Synthetic pesticides like metaldehyde (2,4,6,8-tetramethyl-1,3,5,7-tetraoxacyclooctane) and niclosamide
(2,5-dichloro-4-nitrosalicyanilide) are commonly used molluscicides targeting the GAS.
Wu, "Metabolism of the anthelmintic drug niclosamide
by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1," Xenobiotica, vol.
Bidinosti et al., "Structure-activity analysis of niclosamide
reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling," Journal of Biological Chemistry, vol.
The population control of transmitter mollusks is done with niclosamide
, a molluscicide recommended by the World Health Organization for control programs [1-3].
Lai, "Drug screening identifies niclosamide
as an inhibitor of breast cancer stem-like cells," PLoS ONE, vol.
Additionally, a drug that has been used to treat helminth infections, niclosamide
, inhibited viral growth.
Environmental impact of two molluscicides: niclosamide
and metaldehyde in a rice paddy ecosystem.
Toxicity of Euphorbia milii latex and niclosamide
to snails and nontarget aquatic species.