nick

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nick

(nik),
In molecular biology, hydrolytic cleavage of a phosphodiester bond in one strand of a double-stranded polynucleic acid. Compare: cut.

nick

Etymology: ME, nyke, notch
a split in a single strand of DNA that can be made with the enzyme deoxyribonuclease or with ethidium bromide. See also cut.

nick

Molecular biology
noun A single-strand break in a double-stranded nucleic acid, usually DNA, at which point either one or more nucleotides are absent or there is a break in the phosphodiester bond between two adjacent nucleotides on one strand of the nucleic acid (DNA) duplex. Nicked sites are characterised by increased mobility.

verb To effect a nick in a double-stranded nucleic acid (usually DNA).

nick

a single-stranded cut or break in a DNA molecule. Nicking of DNA may form part of a DNA repair mechanism, as occurs after damage caused by, for example, ultraviolet light.

nick

1. said of a mating that is likely to produce superior offspring.
2. slang for body condition; an animal in good body condition is said to be in good nick.
3. a break in a strand of nucleic acid.
References in classic literature ?
He laid it on the edge of the pen; the knife-blade glimmered with a sound of tearing, and the fish, slit from throat to vent, with a nick on either side of the neck, dropped at Long Jack's feet.
But his father made a fuss about it and said he wouldn't give Nick any land if he married me, so he's going to marry Annie Iverson.
Why, I always called you Nick in my heart, and though lost to sight, to memory dear.
But Ozma soon conquered her, with the help of Glinda the Good, and after that I went to live with Nick Chopper, the Tin Woodman.
He's the brightest man in all the world, is dear Nick Chopper; and the kindest-hearted.
And here is where Nick Chopper destroyed the Wicked Witch's Grey Wolves.
I don't believe Old Nick can be so very, ugly" said Aunt Jamesina reflectively.
His name is Nick Chopper, and he has a lovely heart given him by the wonderful Wizard.
Ashputtel and Nick did their best to cheer her, but they too, seemed to pine for country freedom and home atmosphere.
     Said Nick -- "I'll cook their food in't.
Let Dorothy transform the King into a goose-egg unless he agrees to go into the palace and bring out to us the ornament which is our friend Nick Chopper, the Tin Woodman.
My dear boy, my dear Nick, I give you joy--health, happiness, every blessing