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In molecular biology, hydrolytic cleavage of a phosphodiester bond in one strand of a double-stranded polynucleic acid. Compare: cut.
Etymology: ME, nyke, notch
a split in a single strand of DNA that can be made with the enzyme deoxyribonuclease or with ethidium bromide. See also cut.
noun A single-strand break in a double-stranded nucleic acid, usually DNA, at which point either one or more nucleotides are absent or there is a break in the phosphodiester bond between two adjacent nucleotides on one strand of the nucleic acid (DNA) duplex. Nicked sites are characterised by increased mobility.
verb To effect a nick in a double-stranded nucleic acid (usually DNA).
nicka single-stranded cut or break in a DNA molecule. Nicking of DNA may form part of a DNA repair mechanism, as occurs after damage caused by, for example, ultraviolet light.
1. said of a mating that is likely to produce superior offspring.
2. slang for body condition; an animal in good body condition is said to be in good nick.
3. a break in a strand of nucleic acid.