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In molecular biology, hydrolytic cleavage of a phosphodiester bond in one strand of a double-stranded polynucleic acid. Compare: cut.
noun A single-strand break in a double-stranded nucleic acid, usually DNA, at which point either one or more nucleotides are absent or there is a break in the phosphodiester bond between two adjacent nucleotides on one strand of the nucleic acid (DNA) duplex. Nicked sites are characterised by increased mobility.
verb To effect a nick in a double-stranded nucleic acid (usually DNA).