The a-secretase complex, comprising four essential protein subunits including presenilin, presenilin enhancer 2, nicastrin, and anterior pharynx defective 1, is a transmembrane protease that controls a number of important cellular functions through substrate cleavage.
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Four proteins are required for this complex: PS1 or PS2, nicastrin
, presenilin enhancer 2, and anterior pharynx defective 1.
The [beta]-secretase (BACE1, transmembrane aspartyl protease) initiates endoproteolytic cleavage giving rise to N-terminus of A[beta] ([beta]-secretase cleaved APP to [beta]CTF as the intermediate) followed by [gamma]-secretase (membrane-embedded aspartyl protease complex consisting of presenilin, PS), presenilin enhancer-2 (Pen-2), anterior pharynx defective-1 (Aph-1), and nicastrin
, which reveals the C-terminus of A[beta] .
mutations in French families with hidradenitis suppurativa.
secretase activity is confined to a complex consisting of presenilin (PSEN), nicastrin
(NCT), APH-1 and PEN-2.
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin
, Aph-1, and Pen-2.
Gamma secretase is a membrane protein complex comprised of presenilin, nicastrin
, Aph-1 and Pen-2.
acts as a substrate recognition component of GS at the membrane .
modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Using cultured human cells, as well as test-tube assays, university researchers singled out how just one portion of the enzyme, a protein called nicastrin
, is involved in the pathway that produces beta-amyloid, thereby leading to Alzheimer's disease.
sup] found independent loss-of-function mutations in presenilin enhancer gamma-secretase subunit ( PSENEN ), presenilin 1 ( PSEN1 ), or Nicastrin
( NCSTN ), which encode essential components of the a-secretase multiprotein complex.