nexin

SERPINE2

A gene on chromosome 2q33-q35 that encodes a serine protease inhibitor that acts on thrombin, trypsin and urokinase; it promotes neurite extension by inhibiting thrombin.
Mentioned in ?
References in periodicals archive ?
Guava Nexin assay (Millipore Billerica, USA) was used to detect the apoptosis of GH3 cells.
Gene ID Symbol Official full name 8409 UXT Ubiquitously expressed prefoldin-like chaperone 150684 COMMD1 Copper metabolism domain-containing 1 1278 COL1A2 Collagen type I alpha 2 2335 FN1 Fibronectin 1 4522 MTHFD1 Methylenetetrahydrofolate dehydrogenase 1 5193 PEX12 Peroxisomal biogenesis factor 12 57231 SNX14 Sorting nexin 14 10572 SIVA1 SIVA1 apoptosis-inducing factor 10742 RAI2 Retinoic acid-induced 2 22902 RUFY3 RUN and FYVE domain-containing 3 10456 HAX1 HCLS1-associated protein X-1 3492 IGH Immunoglobulin heavy locus
This clinically distinguishable recessive syndrome consists of cerebellar atrophy, ataxia, coarsened facial features, and intellectual disability and is due to loss-of-function mutations in the sorting nexin 14 gene.
Translated protein from SNX10 gene has 201 amino acids and belongs to Sorting Nexin (SNX) family that are cytoplasmic and membrane-associated proteins playing various roles in endocytosis and protein trafficking (4).
Citron, "Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system," Seminars in Thrombosis and Hemostasis, vol.
Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.
Other ultrastructural defects those lead to ineffective ciliary motility include isolated absence of inner dynein arms or radial spokes, transposition of microtubules to the center of axoneme, missing nexin links etc., [sup][2] The clinical diagnosis of PCD is established in:
Finally, two protease inhibitors (Lipocalin-2/NGAL and Protease Nexin II) showed a peculiar increase in the normoalbuminuric group and a sharp decrease in the macroalbuminuric cohort.
The NECT project is anticipated to significantly impact the nexin and pannexin research area, as it foresees the development and optimisation of new tools and technology to study nexin hemichannels and pannexin channels.
Apoptotic cells were determined with Guava Nexin Reagent (Millipore, USA) according to the manufacturer's protocol.
(30) Further to this, splice variants containing the insert sequences corresponding to the Kunitz-type protease inhibitor (KPI) domain have been identified as protease Nexin II, an endogenous inhibitor against a group of serine proteases including thrombin.
Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have new evidence that points to a protein called sorting nexin 27, or SNX27.