On day 3 after admission, he was prescribed 300 mg zidovudine twice daily, 150 mg lamivudine twice daily and 200 mg nevirapine
Policy makers can now make informed decisions regarding the WHO 2010 prevention of mother-to-child transmission (PMTCT) guidelines and the combined use of nevirapine
and co-trimoxazole prophylaxis for extended periods of time.
The clinics followed NACO guidelines for PPTCT and administered a single dose of nevirapine
to the mother at the time of delivery and one dose to the infant within 72 h after birth.
The NIH, excited about the very encouraging preliminary results, even released the data before its publication in the peer-reviewed literature, reporting an astonishing 48% decrease in HIV transmission with nevirapine
compared with the group receiving a short course of the control, AZT, the previous standard approach to the problem of mother-infant transmission.
Severe hepatotoxicity associated with nevirapine
use in HIV-infected subjects.
increases High Density Lipoprotein-cholesterol by stimulation of apolipoprotein AI synthesis.
Reductions in blood levels of contraceptive hormones due to interactions with nevirapine
or ritonavir can be substantial.
Where no interventions are used, MTC transmission rates are around 40% and a single dose of nevirapine
will nearly halve transmission and is commonly the only means of reducing transmission in developing countries.
4%) had received non-NRTIs (59 patients received only efavirenz, 30 received only nevirapine
, and 5 received both) and 53 patients (41.
Morbilliform eruptions appear in 19% of patients treated with nevirapine
, including 8% who develop Stevens-Johnson syndrome, "a pretty high number," Dr.
SAN FRANCISCO -- Pregnant women given a single dose of nevirapine
during pregnancy to prevent vertical transmission of HIV were more likely to fail their own HIV treatment if it was started within 6 months of taking the nevirapine
, Shahin Lockman, M.
based in Cork, Ireland and now part of Johnson & Johnson, is a "second generation" NNRTI (non-nucleoside reverse transcriptase inhibitor)--an antiretroviral in the same class as efavirenz (brand name Sustiva, or Stochrin in many countries) or nevirapine