In our study, although the mucosal healing was not observed in any of the groups, the statistical analysis for neutrophilic
infiltration showed no significant difference.
It has been observed that the neutrophilic
response to G-CSF was greater in neutropenic patients compared to non-neutropenic ones.18 Available local studies on use of G-CSF in Pakistan are limited to adults and older children with febrile neutropenia or cancer.
Another hypothesis is that NEH is a neutrophilic
dermatitis and that these entities can be seen as paraneoplastic conditions (3-6).
The use of etanercept in classic febrile neutrophilic
dermatosis is not well documented and has been recorded only three times.
Sweet Syndrome, also denominated acute neutrophilic
dermatosis, has been associated both with autoimmune diseases such as ANCA vasculitides, and drugs, namely AZA (1).
"There is still a high unmet medical need in treating the chronic inflammation in patients with cystic fibrosis and other neutrophilic
In conclusion, we report a case of azathioprine hypersensitivity with cutaneous manifestations of neutrophilic
dermatoses along with elevated serum CRP and procalcitonin.
Based on the clinical course of leg lesions exhibiting a pathergic phenomenon in response to skin trauma and nonresponse to multiple adequate courses of antimicrobial therapy and pathology showing sterile neutrophilic
infiltration, combined with diagnosis of underlying hematological malignancy, we diagnosed him clinically with pyoderma gangrenosum.
Furthermore, diffuse neutrophilic
emperipolesis was observed in cancer cells by microscopic evaluation.
Skin biopsy from patients with the disorder is categorized as a neutrophilic
urticarial dermatosis with histopathology demonstrating perivascular and interstitial neutrophilic
inflammation with leukocytoclasia but without leukocytoclastic vasculitis [2, 5].
Blood cultures remained negative and her white cell count reached 14.5 x [10.sup.3]/uL with neutrophilic
change (89.7%) and without band form on the fourth day after admission.
Antineutrophil cytoplasmic antibodies of IgA class in neutrophilic
dermatoses with emphasis on erythema elevatum diutinum.