In a separate oral presentation, Kevin Goncalves, Ph.D., Magenta Therapeutics, highlighted data showing that MGTA-456 significantly improves engraftment and the number of human microglia in the brains of transplanted mice; Tony Boitano, Ph.D., Magenta Therapeutics, presented a third data set showing that MGTA-456 contains large doses of the cells responsible for engraftment, which are also correlated with rapid neutrophil recovery
in patients following transplant.
In fact, IPF has been found to show recovery faster than absolute neutrophil recovery
It should be noted that the 'typical' bone marrow abnormality seen in cyclic neutropenia, namely hypoplasia of the myeloid series with maturation arrest at the myelocyte stage, was not seen in our patient; however, this occurs during the declining phase of the neutrophil oscillation, and myelopoiesis can be normal or even hyperplastic during neutrophil recovery
was defined as having occurred after the first of 3 days with an absolute neutrophil count >500/[micro]l after the post-transplant nadir.
Pegfilgrastim administered in an abbreviated schedule, significantly improved neutrophil recovery
after high-dose radiation-induced myelosuppression in rhesus macaques.
The study also established early clinical proof-of-concept--trends of accelerated neutrophil recovery
, improved 100-day survival and low rates of graft-versus-host disease were evident, and durable and preferential reconstitution with ProHema occurred in 10 of 12 evaluable patients.
Glucans enhance neutrophil recovery
following sub-lethal irradiation (Gu et al., 2005).
In patients receiving MPC-expanded cord blood, the median time to neutrophil recovery
was 16 days and to platelet recovery 38 days, compared with approximately 30 days and over 90 days, respectively, in published reports of patients transplanted with an unexpanded cord.
Moreover, a linear relationship between the occurrence of oral mucositis, oral and systemic granulocyte counts, and a coincidence of resolution of mucositis with neutrophil recovery
has been demonstrated (Kostler et al., 2001).
Moreover, cyclosporine used alone was significantly better at improving outcome than its combined use with other drugs, achieving a neutrophil recovery
probability of 73% at day 40.
During the quarter, Amgen presented preliminary phase 2 data at the annual meeting of the American Society of Hematology demonstrating that neutrophil recovery
following a single injection of a sustained duration version of NEUPOGEN was equal to that of multiple daily doses of NEUPOGEN.