matrix metalloproteinase 2

(redirected from neutrophil gelatinase)

matrix metalloproteinase 2

A 62-kD tissue enzyme encoded on chromosome 16q13-q21 that degrades collagens and other matrix proteins, and which may be linked to cancer.

Cytokine inducers
Activin, CD40L, EGF, endothelin-1, FGF-b, FGF-3, G-CSF, GM-CSF, HGF, IFN-α, IFN-γ, IGF-1, IL-1α, IL-1β, IL-3, IL-6, sIL-6 Rα, IL-8, IL-18, LIF, M-CSF, MIF, oncostatin M, PDGF, SCF, TGF-α, TGF-β1, TNF-α, VEGF.
 
Substrates
3 α-chains of native Collagens I, IV, V, VII, X, XI, and XIV; gelatin, elastin, fibronectin, laminin-1, laminin-5, galectin, aggrecan, decorin, hyaluronidase-treated versican, proteoglycan link protein, osteonectin, MBP, GST-TNF/TNF peptide, IL-1β, serum amyloid A, APP695, α1-AT, prolysyl oxidase fusion protein, IGF-BP5, IGF-BP5, FGF R1, MMP-1, MMP-9, MMP-13.
References in periodicals archive ?
These remain our renal biomarkers of choice until the use of newer renal biomarkers, such as neutrophil gelatinase associated lipocalin and cystatin C, becomes commonplace.
The report analyses the market size and volume of key biomarkers such as Serum Creatinine (SCr) and Neutrophil Gelatinase Associated Lipocalin (NGAL) in Germany.
The session will present a strong overview of acute cardiac and renal illnesses and relate the emerging clinical acceptance of new biomarkers like troponin and neutrophil gelatinase associated lipocalin (NGAL) for rapid diagnosis and management of these patients.
Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.

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