neutral mutation


Also found in: Encyclopedia, Wikipedia.

neu·tral mu·ta·tion

a mutation with a negligible impact on genetic fitness.
Farlex Partner Medical Dictionary © Farlex 2012

neu·tral mu·ta·tion

(nū'trăl myū-tā'shŭn)
A mutation with a negligible impact on genetic fitness.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The negative value of a Tajima's D test, however, was insignificant which specifies that the population contains neutral mutations and highlights the genetic drift as the mode of evolution rather than positive or direct selection (Tajima, 1989) as compared to results found in domestic goat which indicated the positive selection as the mode of evolution (Gade et al., 2010; Pawar et al., 2013).
The sequence of COI in 6 generations was tested by Tajima's D value, and not significant, which were consistent for a neutral mutation. Suggesting that there was no population expansion in the transmission process, and the population size was stable, which showed that the program was effective.
From their data they constructed a lineage that could explain the global distribution of neutral mutations. Combining this with the molecular-clock estimates and with what is known about the timing of human migrations, they concluded that the best explanation of their data was that every human being can trace their lineage back to one woman who lived in Africa about 300,000-150,000 years ago, a woman quickly dubbed "the mitochondrial Eve."
Whereas the SNP at 116 locus may be a neutral mutation which does not affect the cashmere traits.
Thus, neutral mutations are the ones left over after the purifying selection filter - these are the mutations that can exist as polymorphisms with the potential to fix and contribute to divergence among species.
These values are consistent with rates of assortative recombination that are, on the average, an order of magnitude greater than the neutral mutation rate (i.e., 10 [less than or equal to] 2Nc [much less than] 100) and correspond to a rate of recombination that is less that [10.sup.-6] per gene segment per genome per generation.
The eventual outcome of sequence divergence depends on four population-genetic parameters: the expected intra-taxon diversity, the baseline rate of intertaxon recombination, the sensitivity of the recombination rate to sequence divergence, and the neutral mutation rate.
Consideration of genetic correlations using biplot is a first step in jointly understanding the roles of neutral mutation and natural selection.
Current versus historical population sizes in vertebrate species with high gene flow: A comparison based on mitochondrial DNA lineages and inbreeding theory for neutral mutations. Molecular Biology and Evolution 5:331-344.
Model of effectively neutral mutations in which selective constraint is incorporated.
Near neutral mutations occur at high frequencies and have higher impact on fitness.