ASAH2

(redirected from neutral ceramidase)

ASAH2

A gene on chromosome 10q11.23 that encodes an amidohydrolase which hydrolyses ceramide into sphingosine and free fatty acid, acting as a key regulator of sphingolipid-signalling metabolites by generating sphingosine at the cell surface. It represses apoptosis by reducing C16-ceramide (preventing ceramide-induced apoptosis) and by generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate.
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References in periodicals archive ?
An additional source of ceramide in mitochondria is via the reverse activity of neutral ceramidase, and recent reports also describe ceramide formation from acylCoA and sphingosine mediated by the coupled activities of mitochondrial neutral ceramidase and thioesterase.
In the plasma membranes, Sph is formed by neutral ceramidase in the presence of divalent cations at neutral pH [8].
Awards for original research papers published in the Hamdan Medical Journal are: - Purification and biochemical characterisation of a second type of neutral ceramidase from camel (Camelus dromedarius) brain, by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.
*'Purification and biochemical characterisation of a second type of neutral ceramidase from camel (Camelus dromedarius) brain', by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE