ASAH2

(redirected from neutral ceramidase)

ASAH2

A gene on chromosome 10q11.23 that encodes an amidohydrolase which hydrolyses ceramide into sphingosine and free fatty acid, acting as a key regulator of sphingolipid-signalling metabolites by generating sphingosine at the cell surface. It represses apoptosis by reducing C16-ceramide (preventing ceramide-induced apoptosis) and by generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate.
References in periodicals archive ?
Awards for original research papers published in the Hamdan Medical Journal are: - Purification and biochemical characterisation of a second type of neutral ceramidase from camel (Camelus dromedarius) brain, by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.
Purification and biochemical characterisation of a second type of neutral ceramidase from camel (Camelus dromedarius) brain', by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE