conducted their own study of neurotrophic ulcer
treatment with RGTA[R], where the outcomes were not so much satisfying from the efficacy point of view.
An obese 60-year-old male patient with a 10-year diabetes history presented with a chronic neurotrophic ulcer
on the lateral side of the fifth toe that had been present for three years (Figure 4a).
Number of % patients Age (years) <20 3 6 21-39 25 49 40-64 14 27 >65 9 18 Sex Male 29 57 Female 22 43 Risk factors Contact lens wear 23 45 Foreign body 6 12 Recurrent corneal erosion 5 10 Corneal graft 4 8 Skin condition 2 4 Exposure keratopathy 2 4 Bullous keratopathy 1 2 Herpetic keratitis 1 2 Neurotrophic ulcer
1 2 Ocular trauma 1 2 Trichiasis 1 2 No risk factor 4 8 Table 2: Organisms isolated and predisposing factors in patients with microbial keratitis cases treated at a university hospital in Hong Kong between 2012 and 2014.
Walther, "Squamous-cell carcinoma arising in a leprous neurotrophic ulcer
: report of a case," The Journal of Dermatologic Surgery and Oncology, vol.
Ocular diseases requiring lid fusion included, infective corneal ulcer/abscess in 21 cases (65.6 %), shield ulcer in vernal keratoconjunctivitis in 3 cases (9.4 %), facial palsy in 2 cases (6.2 %), alkali burns in 2 cases (6.2%), neurotrophic ulcer
in 2 cases (6.2 %), Mooren ulcer in 1 case (3.1 %), Grave's disease in 1 case (3.1%).
Exclusion criteria: Non suppurative keratitis including viral keratitis, neurotrophic ulcers
, degenerative causes were excluded as were Moorens ulcer, interstitial keratitis, sterile neurotrophic ulcers
and any ulcer associated with systemic autoimmune conditions.
Although positive results have been demonstrated in both experimental and clinical investigations regarding the speed of the peripheral nerve regeneration when using PRP for more severe epitheliopathies such as neurotrophic ulcers
, we believe the same effect was not obtained in our previous study due to the limited bioavailability of growth factors in corneal stroma when the substance is topically administered .