Various other terms also had been used for the dermal neoplasms, such as neurothekeoma
, nerve sheath myxoma, benign myxoid tumor of nerve sheath, perineural myxoma, bizarre cutaneous neurofibroma.
This can usually be accomplished by immunohistochemistry for markers of melanocytic differentiation, such as S100 and/or Melan-A, which would be positive in melanocytic lesions and negative in cellular neurothekeoma
and fibrohistiocytic lesions.
Other pathological differential diagnoses of our case would include hybrid peripheral nerve sheath tumors, perineurioma, cellular neurothekeoma, nerve sheath myxoma (classic neurothekeoma), desmoplastic neurothekeoma, superficial angiomyxoma (cutaneous myxoma), (16) solitary neurofibroma with prominent differentiation of Meissner bodies, or spindle cell carcinoma.
Benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma arising from the nose.
It is notably absent in cellular neurothekeoma, Langerhans cell histiocytosis, perineurioma, MCC, spindle cell SCC, AFX, and leiomyosarcoma.
Nerve sheath myxomas, believed to be of peripheral nerve sheath origin, were redesignated as neurothekeoma by Gallager and Helwig (224) in 1980.
5, also known as ubiquitin carboxyl-terminal hydroxylase-1) reactivity can be helpful in the diagnosis of neurothekeoma but also suffers from low specificity.
Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma.
Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma.
When they are pigmented they can be misdiagnosed clinically as malignant melanoma, bednar tumor, mycosis fungoides and neurothekeoma
23) MiTF is less specific, with expression in nonmelanocytic lesions, including histiocytic lesions and cellular neurothekeoma
Of the several antigens detected by anti-S100, A6 is expressed by some melanocytic lesions and is also a very helpful marker to detect neurothekeomas