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Steroid produced within the brain.
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Some of the beneficial neurosteroid effects of pregnenolone result from an increased activity of brain cells.
Neurosteroid modulation of [GABA.sub.A] receptors: Molecular determinants and significance in health and disease.
In two steps, of which 5[alpha]-R is rate-limiting, these enzymes convert progesterone within the brain to the polysyllabic neurosteroid 3[alpha],5[alpha]-tetrahydro-progesterone (also called allopregnanolone, or simply "ALLO") --see Figure 2.
PH10 is a neurosteroid with a differentiated mechanism of action.
As we have noted elsewhere, (3) the research underlying the discovery of endogenous neurosteroids and their role in modulating GABA receptors laid the foundation for the development of brexanolone, an intravenous formulation of the neurosteroid allopregnanolone.
Loneliness is linked to the decrease of a neurosteroid called pregnenolone, which improves stress-related disorders and calms the hyper-vigilance in the brain caused by social threats.
Alfaxalone, an injectable neurosteroid anesthetic, enhances binding of GABA to the [GABA.sub.A] receptor, causing central nervous system depression, unconsciousness, and muscle relaxation.
Another functional steroid, neurosteroid, function as neurotransmitters in the brain.
Allopregnanolone is an endogenous neurosteroid with potent GABA modulation which demonstrated anti-convulsant properties in animal models [103].
It has a variety of important functions in the body and is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and corticosteroids, and plays an important role in brain function as a neurosteroid [2, 5].
Jain, "Antidepressant-like effect of the neurosteroid 3a-hydroxy-5a-pregnan-20-one in mice forced swim test," Pharmacology Biochemistry & Behavior, vol.