KLK8

(redirected from neuropsin)

KLK8

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses the degradation of casein, fibrinogen, kininogen, fibronectin and collagen type IV. It cleaves L1CAM in response to increased neural activity, and induces neurite outgrowth and fasciculation of cultured hippocampal neurons.
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During experiments on mice, the researchers identified a protein, called neuropsin, which is made in the amygdala, the brain's "fear centre".
In times of stress, it was found that the brain makes more neuropsin which triggers a series of chemical reactions that culminate in a "fear gene" being switched on, and the feelings of anxiety.
The protein neuropsin is regulated by the amygdala, a region deep in the brain that plays a key role in emotional responses.
New British-led research suggests neuropsin underlies an individual's susceptibility to stress.
Developing drugs to target the neuropsin biological pathway could provide new treatments for post-traumatic stress disorder and other anxiety conditions.
KLK8 was originally cloned from a human skin library (9) as a homolog of a gene encoding mouse neuropsin.
Serine proteinase inhibitor 3 and murinoglobulin | are potent inhibitors of neuropsin in adult mouse brain.
Originally, KLK8 was cloned from a human skin cDNA library as a homolog of mouse neuropsin (9).
61) have shown that KLKS (also known as neuropsin and TADG-14) is differentially expressed in ovarian cancer.
Two additional kallikrein genes, KLKS (also known as neuropsin or TADG-14) (18) and the gene that encodes stratum corneum chymotryptic enzyme (19,20) are upregulated in ovarian cancer.
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7 PRSS6 hK7 KLKS PRSS19 hK8 KLK9 KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12 KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7 HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9 KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12 KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.
The peropsins are members of the larger Tetraopsin lineage, which includes neuropsins, Go-opsins, retinal G protein-coupled receptor opsins, and retinochromes (Ramirez et al.