neuroprotection


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neuroprotection

(nūr″ō-prō-tĕk′shŭn)
The science of minimizing secondary neurologic damage following stroke or trauma. Certain drugs, enzymes, hormones, and physical actions, such as inducing hypothermia, may act as neuroprotectors.

neuroprotection

A therapeutic strategy aimed at preventing the ultimate result of a neurodegenerative disease process. Example: in current glaucoma therapy, the principal objective is to lower the intraocular pressure, but that appears to be only one of the risk factors that lead ultimately to shrinkage and/or death of retinal ganglion cells and visual field loss. Visual field losses occur even after the intraocular pressure is returned to within the normal range in some patients. Neuroprotection is aimed at preventing that secondary ganglion cell degeneration in glaucomatous eyes, which may have been caused as a result of inflammatory or toxic mediators released by the primary degenerative event. Neuroprotective strategies presently being evaluated include glutamate antagonists, calcium channel blockers, nitric oxide synthase inhibitors and neurotrophins.
References in periodicals archive ?
M2 PRESSWIRE-August 1, 2019-: Neuroprotection Methods, Drugs, Markets and Companies Research Repoer 2019: Profiles of 140 Companies with 126 Collaborations
Our central hypothesis is that long-term gene delivery of COMP-Ang1 (angiopoietin-1 combined with the short coiled-coil domain of cartilage oligomeric matrix protein) has efficacy in promoting vascular normalization and neuroprotection in the presence of retinal ischemia.
Silk Road Medical announced final results for the company's ROADSTER-2 post-marketing study evaluating real world use of the ENROUTE Neuroprotection and Stent Systems in TransCarotid Artery Revascularization procedures.
Summary: This report on the Neuroprotection Market analyzes the current and future scenario of the global market.
[UKPRwire, Wed Jun 12 2019] This report on the Neuroprotection Market analyzes the current and future scenario of the global market.
The publication entitled, "Effects of Varying Intranasal Treatment Regimens in ST266-Mediated Retinal Ganglion Cell Neuroprotection," details the preclinical study exploring the neuroprotective effects of daily and twice daily intranasally delivered ST266 to evaluate different treatment regimens an EAE-induced experimental ON mouse model.
The clinician should start neuroprotection strategies and treat the GI tract in the setting of BBB permeability.
These findings persisted even when potentially confounding factors, like birth weight, gestational age, foetal sex or other treatments, such as magnesium sulfate given for neuroprotection, were evaluated.
Neuroprotection has been considered for many years as an alternative strategy to limit the extent of irreversible damage to neuronal cells after brain injury, including aneurysmal SAH (2).
He has been active in research at Karolinska Institutet, focusing on neuroprotection treatment in premature and newly born infants, family-centred care and the design of health care and medical care.
The main concern is the safety of using a minimally invasive approach for such a high-risk surgery.[1] Here, we introduce a technique to perform a preferential reconstruction of the arch vessels with complete cerebral perfusion technique during hypothermic circulatory arrest (HCA) to improve neuroprotection.
The focus of the laboratory is the pathophysiology of stroke and traumatic brain injury; mechanisms of neuroprotection, cell-based and pharmacological neurorestorative therapies for stroke, traumatic brain injury, and neurodegenerative disease.