is currently pursuing NPT520-34 for the treatment of both ALS and Parkinson's disease.
Copp, "Relationship between timing of posterior neuropore
closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture," Journal of Embryology and Experimental Morphology, vol.
The transaction will see an initial upfront payment of USD20m made to Neuropore
, which is also entitled to potential development, regulatory and sales-based milestones payments, of up to a potential total of USD460m in addition to royalties on net sales.
Anne Phelan, SVP BenevolentAI, said, 'The collaboration between Neuropore
and BenevolentAI offers a fantastic opportunity to accelerate the discovery of new medicines.
As announced in January 2015, Neuropore
Therapies granted UCB a world-wide license to develop and commercialize alpha-synuclein targeting molecules in all indications.
The essential defect is a failure of closure of the caudal neuropore
has been appointed president and chief executive officer of US-based biopharmaceutical company Neuropore
Ventrally the coelom ends in a blind sac; dorsally it extends extremely posteriorly into the stalk and opens to the outside through a single proboscis pore just left of the dorsal midline of the proboscis stalk and almost into the anterior neuropore
Until complete fusion of the neural plate, the cranial and caudal ends of neural tube communicate with the amniotic cavity through anterior and posterior neuropores
. Closure of cranial neuropore
occurs at about 25th day (8-20 somite stage) whereas the posterior neuropore
closes at about 28th day (25 somite stage).
(2012), the neuropores
(cranial and caudal) were both closed in the agouti at 25 days, the thoracic limbs of the embryos at 35 days showed digit rays at the tips that were not observed on the pelvic limbs, as in human beings at 40 days, on the pelvic limbs the digit rays were observed presenting a shape similar to those of human embryos.
Muller, "The two sites of fusion of the neural folds and the two neuropores
in the human embryo," Teratology, vol.
Spinal dysraphism is a medical term that refers to neurological disorders related to malformations of the spinal cord, which can arise from failure in the closure of caudal neuropores
at the end of the fourth week of embryological life.