also measured ENK neuropeptidase activities in the three main regions of the stress response circuitry (AMG, HPC, and mPFC) after acute restraint in rats (see Table 2; ).
Segarra et al., "Interaction of neuropeptidase activities in cortico-limbic regions after acute restraint stress," Behavioural Brain Research, vol.
Coyle, "Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase
," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Diabetes mellitus as a serious metabolic disorder characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins (Lebed et al, 2008) and is associated with cerebral alterations (Biessels et al., 2002; Gispen & Biessels, 2000; McCall, 1992) including abnormal expression of hypothalamic neuropeptidase
, hippocampal astrogliosis (Saravia et al., 2002) decreased hippocampal synaptic plasticity, neurotoxicity, changes in glutamate neurotransmission (Gardoni et al., 2002) and hippocampal neuron density are dysfunctions of the central nervous system (Golalipour et al., 2012).
(2003) Perspectives: Alzheimer's disease, neuropeptides, neuropeptidase
, and amyloid-[beta] peptide metabolism.
Pinto et al (18) have demonstrated that PSMA has folate hydrolase activity, and others have shown a neuropeptidase
Processing and Metabolism of Neuropeptidase
. In: Essays in biochemistry (eds.
Beside its established antioxidant properties green tea extract seems to influence also the expression of the neuropeptidase NEP included in the degradation of amyloid peptides and it also seems to diminish the risk of accumulation of plaque forming peptides.
In order to see if green tea influences the expression of neuropeptidases we used the neuroblastoma cell line SK-N-SH and studied changes in the specific cellular enzyme activity of NEP and ACE after long term treatment with green tea extract.